Rapid breakthrough of131 I in an in vitro human epidermis model

Toxicology in Vitro : an International Journal Published in Association with BIBRA
U NygrenL Thors

Abstract

Skin contamination with radionuclides may cause local radiation damage, but also systemic distribution if the nuclides penetrate the epidermal membrane. Detailed information of the skin absorption of radionuclides is of importance for e.g. dose estimations and development of decontamination strategies. In the present study, penetration of131I through human epidermis was studied using an in vitro flow through diffusion chamber. Epidermis was exposed to a Na131I-solution, used in nuclear medicine, and the potential concentration-dependency of skin penetration was examined by including two concentrations of non-radioactive NaI. Penetration of131I occurred after a few minutes of exposure and steady state penetration rate was obtained after about 50-70min independently of the iodine concentration and receptor solution used. The two receptor solutions evaluated; phosphate buffered saline solution and an ethanol and water-mixture (1:1), resulted in significantly higher penetration rate of131I using the ethanol and water-mixture. The penetration of iodine was calculated to be concentration-dependent independently of the receptor solution utilized. In addition, radioactive iodine did not accumulate in epidermis in the in vitro-model use...Continue Reading

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Citations

Dec 4, 2019·Scandinavian Journal of Occupational Therapy·Kim WalderGail Whiteford
Oct 23, 2020·International Journal of Pharmaceutics·Małgorzata TarnowskaMarie-Alexandrine Bolzinger

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