Rapid bupropion-induced hepatotoxicity: a case report and review of the literature

Journal of Medical Case Reports
Sulakchanan Anandabaskaran, Vincent Ho

Abstract

Bupropion is an antidepressant that is also used as a non-nicotine method to aid in smoking cessation. Bupropion-induced hepatotoxicity is quoted to affect between 0.1% and 1% of treated patients with either a hepatocellular and/or cholestatic pattern of damage. The mechanism of damage is considered to be predominantly immune-mediated with the presence of a hypersensitivity syndrome (fever, rash, eosinophilia, autoantibodies) and a short latency period (1-6 weeks). We believe our reporting of this case to the already existing small list of only seven cases in the world literature will help practicing physicians to deal with the diagnostic and management dilemmas that bupropion-induced hepatotoxicity brings. A 50-year-old Caucasian woman presented to our hospital with significant derangement of liver transaminases after 6 days of bupropion treatment for smoking cessation. The patient's other medications were considered unlikely to be the cause of the hepatotoxicity and were therefore continued. The patient's liver function tests normalized on withdrawal of bupropion, confirming that bupropion was the probable cause of the patient's hepatotoxicity. We conclude that hepatotoxicity is a rare adverse effect of bupropion use, but phy...Continue Reading

References

Oct 1, 1993·Journal of Clinical Psychopharmacology·D W Oslin, K Duffy
Oct 29, 2000·Digestive Diseases and Sciences·K Q HuA G Redeker
Jan 12, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·D AlvaroA F Atili
Jan 29, 2003·The Annals of Pharmacotherapy·Ai-Leng KhooGek-Kee Lim
Jul 19, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Einar Björnsson, Rolf Olsson
Sep 20, 2007·Journal of Medical Case Reports·Fawwaz HumayunRobert J Fontana
Oct 22, 2008·Gastroenterología y hepatología·José Carlos Titos-ArcosJoaquín Plaza-Aniorte
Mar 17, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Yu WangXiao-Jun Huang
May 4, 2010·Gastroenterología y hepatología·Laura Alonso RodríguezLaura Rodríguez Pérez
Dec 24, 2013·The American Journal of Psychiatry·Cosmin Sebastian VoicanGabriel Perlemuter
Oct 28, 2015·ACG Case Reports Journal·Derek M TangHyosun Han

❮ Previous
Next ❯

Methods Mentioned

BETA
hormone replacement therapy
biopsy
biopsies
SMA

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
Amy E Tackett, Kelly M Smith
Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
Sean M BagshawThomas J Bowen
Nederlands tijdschrift voor geneeskunde
E J WagenaC P van Schayck
Nederlands tijdschrift voor geneeskunde
J S Burgers, J R van der Laan
© 2022 Meta ULC. All rights reserved