PMID: 9163339Apr 15, 1997Paper

Rapid Ca2+ influx induced by the action of dibutylhydroquinone and glucagon in the perfused rat liver

The Biochemical Journal
T L ApplegateF L Bygrave

Abstract

Glucagon induces a slight Ca2+ efflux when administered to the perfused rat liver. However, the hormone promotes rapid and significant Ca2+ influx after the prior administration of 2, 5-di(t-butyl)-1,4-hydroquinone (BHQ), an agent that promotes Ca2+ release from the endoplasmic reticulum (ER). The concentrations of glucagon that promote Ca2+ influx are similar to those that promote glycogenolysis and gluconeogenesis in isolated hepatocytes. The permeable analogue of cAMP, but not that of cGMP, is able to duplicate the Ca2+-mobilizing effects of glucagon. The influx of Ca2+ into liver is blocked by Ni2+. Administration of sodium azide, an inhibitor of mitochondrial electron transport, also blocks the BHQ plus glucagon-induced Ca2+ influx and this is reversed when azide administration is terminated. The actions of azide are evident within 60 s after administration or withdrawal, and also occur when either oligomycin or fructose is co-administered; this provides evidence for an effect of azide independent of cellular ATP depletion. Measurement of total calcium in mitochondria that were isolated rapidly from perfused livers after the combined administration of glucagon and BHQ confirmed that large quantities of extracellular Ca2+ h...Continue Reading

Citations

Mar 24, 2000·Redox Report : Communications in Free Radical Research·S Ryan, V Gogvadze
Feb 23, 2008·Biochimica Et Biophysica Acta·Gregory J BarrittGrigori Y Rychkov
Jul 17, 2004·Shock·Brian G HarbrechtBaochun Zhang
Feb 7, 2009·Clinical and Experimental Pharmacology & Physiology·Greg J BarrittGrigori Y Rychkov
Jan 24, 2007·Physiological Reviews·Jorgina SatrústeguiAraceli Del Arco

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