Rapid change in prescribing behavior in hospitals participating in get with the guidelines-stroke after release of the management of atherothrombosis with clopidogrel in high-risk patients (MATCH) clinical trial results

Stroke; a Journal of Cerebral Circulation
Bijoy K MenonGet With The Guidelines-Stroke Steering Committee and Investigators

Abstract

Physician prescribing patterns change slowly despite published randomized trials and consensus guidelines. We measure the effect of Management of Atherothrombosis With Clopidogrel in High-Risk Patients (MATCH) trial on discharge prescribing patterns for patients with stroke and those with transient ischemic attack in the Get With The Guidelines (GWTG)-Stroke Program. We analyzed discharge prescribing patterns of antithrombotic medications for patients admitted with ischemic stroke or transient ischemic attack at hospitals participating in GWTG-Stroke between October 2002 to January 2006. Clinical information by quarter was analyzed in relation to publication of the MATCH study. Frequency of discharge prescription of aspirin+clopidogrel post-MATCH publication was compared with the pre-MATCH period after adjusting for patient and hospital characteristics and clustering by hospital. A total of 107 872 patients at 632 sites were eligible to receive antithrombotic therapy at discharge. Use of aspirin+clopidogrel therapy declined from 22.4% to 15.4% of patients after the publication of MATCH (adjusted OR 0.62, 95% CI 0.56 to 0.70, P<0.0001). Analysis by quarter revealed a rapid and sustained decrease in use of aspirin+clopidogrel the...Continue Reading

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Jan 8, 2004·JAMA : the Journal of the American Medical Association·Randall S StaffordJun Ma
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Citations

Jul 5, 2011·Clinical and Experimental Pharmacology & Physiology·Chun-Juan WangYong-Jun Wang
Jan 25, 2011·Cardiology Clinics·Kumaran Kolandaivelu, Deepak L Bhatt
Feb 26, 2013·Annals of Neurology·Deborah A LevineSudeep J Karve
Sep 4, 2014·Circulation. Cardiovascular Quality and Outcomes·William R LewisGregg C Fonarow
Dec 7, 2013·Stroke; a Journal of Cerebral Circulation·Daniel T LacklandUNKNOWN Council on Functional Genomics and Translational Biology
Sep 30, 2020·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Kunakorn AtchaneeyasakulJeffrey L Saver
Jun 5, 2013·Stroke; a Journal of Cerebral Circulation·Lee H Schwamm

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