PMID: 8593533Oct 1, 1995Paper

Rapid changes in carbohydrate metabolism in muscle induced by triiodothyronine; the role of glucose 1,6-bisphosphate

Biochemical and Molecular Medicine
M Chen-ZionR Beitner

Abstract

All of the past research on glucose utilization by muscles focused on the slow action of thyroid hormones. Here we show that experimental hyperthyroidism, which was induced in rats by a single intramuscular injection of 3,3', 5-triiodothyronine (T3) at high concentration, resulted in rapid changes (within minutes) in carbohydrate metabolism in tibialis anterior muscle. There was an increase in lactate content, in the allosteric activity of soluble phosphofructokinase (the rate-limiting enzyme in glycolysis), and in its product fructose 1,6-bisphosphate, 5 min following the injection of T3, suggesting stimulation of glycolysis. The allosteric activity of mitochondrial-bound, and, to a lesser extent, of soluble hexokinase, was also enhanced. However, the intracellular distribution of the enzymes was unchanged by the hormone. The allosteric stimulation of hexokinase may be attributed to the decrease in glucose 1,6-bisphosphate, which is a potent inhibitor of hexokinase. The level of glucose 6-phosphate, another unknown inhibitor of hexokinase, was not changed by the hormone. The activation of phosphofructokinase following T3 injection may be attributed to the decrease in ATP, an allosteric inhibitor of the enzyme, and the increase...Continue Reading

Citations

Apr 17, 1998·European Journal of Pharmacology·J Penso, R Beitner
Jun 11, 1997·European Journal of Pharmacology·L Glass-Marmor, R Beitner
Jun 6, 2012·Thyroid : Official Journal of the American Thyroid Association·Silvania Silva TeixeiraMaria Tereza Nunes
Aug 28, 1998·Molecular Genetics and Metabolism·R Beitner
Jul 22, 2010·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·L Y Leung, Norman Y S Woo
Oct 12, 2010·Critical Reviews in Biochemistry and Molecular Biology·Santiago ReyesAlexey E Alekseev

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