Rapid changes in cellular immunity following a confrontational role-play stressor

Brain, Behavior, and Immunity
B D NaliboffJ Pine

Abstract

Recent laboratory studies have shown several immune system changes consistently associated with brief stress including increases in circulating natural killer (NK) cell numbers, increases in NK cell cytotoxicity (NKCC), increases in suppressor cytotoxic (CD8) T cell numbers, and decreases in the in vitro proliferative response to mitogen stimulation. In the present study, we use a confrontational role-play, which brings out responses varying from assertion to capitulation and examine the psychological, behavioral, physiological, and immune system responses to this task compared to a resting control task. Compared to the control condition, the brief confrontational role-play led to significant subjective and physiological arousal and increases in circulating NK (CD16, CD56) as well as large granular lymphocyte (CD57) cells and suppressor/cytotoxic T cells (CD8). There were also significant relationships between stress-related increases in the cardiovascular measures and the numbers of circulating NK cells. These findings support sympathetic nervous system activation as a primary mechanism for increases in NK cell numbers under challenge. These role-play results are generally consistent with those from other laboratory tasks such...Continue Reading

Citations

Jul 15, 2004·Psychological Bulletin·Suzanne C Segerstrom, Gregory E Miller
Jan 7, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S K Agarwal, G D Marshall
Apr 7, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S GonlachanvitW D Chey
Aug 21, 2001·The Journal of Investigative Dermatology·M AltemusR D Granstein
Aug 5, 1998·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·H L LoganS L Berberich
May 31, 2001·Psychosomatic Medicine·H L LoganD Lubaroff
Jan 16, 2003·The American Journal of Gastroenterology·Britta DickhausBruce D Naliboff
Jul 22, 1998·The American Journal of Gastroenterology·T LemboB D Naliboff
Jun 21, 2001·Epidemiology·E D Shenassa
Aug 20, 2020·Nature Reviews. Immunology·Maya SchillerAsya Rolls
Jul 5, 2002·Brain, Behavior, and Immunity·Virginia M Sanders, Rainer H Straub

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.