Rapid Characterization of Components in Bolbostemma paniculatum by UPLC/LTQ-Orbitrap MSn Analysis and Multivariate Statistical Analysis for Herb Discrimination

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Yanling ZengShouying Du

Abstract

Bolbostemma paniculatum is a traditional Chinese medicine (TCM) showed various therapeutic effects. Owing to its complex chemical composition, few investigations have acquired a comprehensive cognition for the chemical profiles of this herb and explicated the differences between samples collected from different places. In this study, a strategy based on UPLC tandem LTQ-Orbitrap MSn was established for characterizing chemical components of B. paniculatum. Through a systematic identification strategy, a total of 60 components in B. paniculatum were rapidly separated in 30 min and identified. Then based on peak intensities of all the characterized components, principle component analysis (PCA) and hierarchical cluster analysis (HCA) were employed to classify 18 batches of B. paniculatum into four groups, which were highly consistent with the four climate types of their original places. And five compounds were finally screened out as chemical markers to discriminate the internal quality of B. paniculatum. As the first study to systematically characterize the chemical components of B. paniculatum by UPLC-MSn, the above results could offer essential data for its pharmacological research. And the current strategy could provide useful ...Continue Reading

References

Dec 30, 1999·Archives of Insect Biochemistry and Physiology·L Zibareva
Aug 5, 2000·Journal of Natural Products·Z T SadikovR Lafont
Aug 23, 2003·Journal of Asian Natural Products Research·Wen-Yong Liu Yun-Zhou
May 5, 2004·Planta medica·Wen-Yong LiuWan-Sheng Chen
Mar 20, 2010·Journal of Chromatography. a·Alexander Makarov, Michaela Scigelova

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Citations

Sep 12, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Li-Xia ZhuZhong-Zhen Zhao
Jul 28, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Fangzhou LiuYang Yang
Aug 23, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhixin WangXiaoya Shang
Jun 24, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jiawei TanShouying Du

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