Rapid clearance of fetal cells from maternal circulation after delivery

Annals of the New York Academy of Sciences
Aggeliki KolialexiAriadni Mavroua

Abstract

We previously reported increased apoptosis in the maternal circulation during pregnancy, partly accounting for the presence of cell-free fetal DNA in maternal plasma. In the current study, apoptosis was quantitated in 60 peripheral blood samples obtained from 15 women sequentially tested postpartum using the binding of annexin V. FISH with X/Y probes was performed on annexin V-positive cells isolated by MACS in patients with male fetuses to estimate the proportion of fetal cells among the apoptotic cell population. Twenty-four women at the thirty-seventh to thirty-eighth week of gestation and 35 nonpregnant females were used as controls. Apoptosis rate in the thirty-seventh to thirty-eighth week was 12.5% (9.2-14.7%). At 30 minutes, 12 hours, 24 hours, and 48 hours postpartum, it was 25.1% (16.8-28.5%), 12.5% (10.9-14.1%), 6.1% (4.8-7.1%), and 2.3% (1.3-3.0%), respectively. Male apoptotic cells were identified in all cases with male fetuses at 37 to 38 weeks of gestation, and the mean proportion was 9.9% (5.9-13.2%). The proportion of fetal cells 30 minutes after delivery was 14.8% (12.5-25.5%) and 12 hours postpartum 2.1% (0.8-4.1%). Male fetal apoptotic cells were detected in three of eight samples collected 24 hours after de...Continue Reading

References

Jun 1, 1992·Trends in Pharmacological Sciences·W BurschR Schulte-Hermann
Oct 1, 1994·Arthritis and Rheumatism·J D MountzT Zhou
Apr 1, 1994·American Journal of Obstetrics and Gynecology·H HamadaT Kubo
Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·D W BianchiM A DeMaria
Oct 23, 1997·American Journal of Human Genetics·D W BianchiA P Shuber
Jan 23, 1999·American Journal of Human Genetics·Y M LoN M Hjelm
Dec 23, 2000·Fetal Diagnosis and Therapy·A KolialexiA Mavrou

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Citations

Nov 20, 2009·The International Journal of Developmental Biology·Hilary S Gammill, J Lee Nelson
Jan 31, 2007·Journal of Autoimmunity·Norbert Gleicher, David H Barad
Sep 1, 2015·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Amy M BoddyAthena Aktipis
Jan 22, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Xiaoyu PanXiuqing Zhang
Jun 18, 2015·BMC Medical Genomics·Dineika ChandranandaMelanie Bahlo
May 1, 2012·Biochimica Et Biophysica Acta·Andrea G Edlow, Diana W Bianchi
Jan 8, 2011·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Osamu Samura
Oct 14, 2017·Briefings in Functional Genomics·Anders StåhlbergThomas Kroneis
Mar 25, 2005·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·S IllanesP W Soothill
Jun 20, 2019·F1000Research·Ondrej PösTomáš Szemes
Aug 14, 2021·Translational Animal Science·J Alison BrownJ Bret Taylor

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