Abstract
Focal cerebral arteriopathy includes unifocal or multifocal lesions that are unilateral or bilateral. Large- and/or medium-sized vessels are involved and can be visualized on angiography. We report a case of cerebral infarction in a 9-year-old Japanese female who presented with a transient ischemic attack. Steno-occlusion involving the distal part of the internal carotid artery, proximal middle cerebral artery, and anterior cerebral artery was observed. Digital subtraction angiography demonstrated a beaded appearance in the cervical portion of the diseased internal carotid artery. Revascularization surgery was performed 45 days after the onset. A new infarction appeared on the other side of the anterior cerebral artery territory 7 months after the first onset. Antiplatelets and vasodilators were administered, and no progression was observed during 18 months of follow-up. Genetic analysis did not show ring finger protein 213 (RNF213)-related moyamoya disease, and pathological examination revealed no characteristics of fibromuscular dysplasia. The radiological and genetic features coincided with focal cerebral arteriopathy, which is a distinct entity from fibromuscular dysplasia and RNF213-related moyamoya disease.
References
Sep 1, 1977·Stroke; a Journal of Cerebral Circulation·A G Osborn, R E Anderson
Nov 22, 2002·Lancet·Ronald SträterUlrike Nowak-Göttl
Nov 28, 2008·Journal of Neurosurgery·Hidehito KimuraEiji Kohmura
Nov 29, 2008·Brain : a Journal of Neurology·K P J BraunG Sébire
Feb 18, 2009·Neurology·R H SwartzD J Mikulis
Mar 4, 2009·Circulation·Catherine Amlie-LefondUNKNOWN International Pediatric Stroke Study Group
Dec 14, 2011·Stroke; a Journal of Cerebral Circulation·Timothy J BernardRebecca Ichord
Mar 2, 2012·Neurology·S MiyatakeN Matsumoto
Aug 9, 2012·Neurologia Medico-chirurgica·UNKNOWN Research Committee on the Pathology and Treatment of Spontaneous Occlusion of the Circle of Willis, UNKNOWN Health Labour Sciences Research Grant for Research on Measures for Infractable Diseases
Jan 8, 2013·Pediatric Neurology·Aleksandra Mineyko, Adam Kirton
May 30, 2013·Brain : a Journal of Neurology·Adam KirtonGabrielle deVeber
Aug 24, 2013·Stroke; a Journal of Cerebral Circulation·Satoru MiyawakiNobuhito Saito
Sep 14, 2013·Cerebrovascular Diseases·Yohei MineharuSusumu Miyamoto
Feb 20, 2014·Stroke; a Journal of Cerebral Circulation·Je Young YeonSeung-Chyul Hong
Nov 13, 2014·Stroke; a Journal of Cerebral Circulation·Max WintermarkUNKNOWN VIPS Investigators
Jul 1, 2015·Pediatric Neurology·Alisha T TolaniJorina Elbers
Nov 12, 2015·Stroke; a Journal of Cerebral Circulation·Heather J FullertonUNKNOWN VIPS Investigators