Rapid Corneal Nerve Fiber Loss: A Marker of Diabetic Neuropathy Onset and Progression.

Diabetes Care
Evan J H LewisBruce A Perkins

Abstract

Corneal nerve fiber length (CNFL) represents a biomarker for diabetic distal symmetric polyneuropathy (DSP). We aimed to determine the reference distribution of annual CNFL change, the prevalence of abnormal change in diabetes, and its associated clinical variables. We examined 590 participants with diabetes (399 with type 1 diabetes [T1D] and 191 with type 2 diabetes [T2D]) and 204 control patients without diabetes with at least 1 year of follow-up and classified them according to rapid corneal nerve fiber loss (RCNFL) if CNFL change was below the 5th percentile of the control patients without diabetes. Control patients without diabetes were 37.9 ± 19.8 years old, had median follow-up of three visits over 3.0 years, and mean annual change in CNFL was -0.1% (90% CI -5.9% to 5.0%). RCNFL was defined by values exceeding the 5th percentile of 6% loss. Participants with T1D were 39.9 ± 18.7 years old, had median follow-up of three visits over 4.4 years, and mean annual change in CNFL was -0.8% (90% CI -14.0% to 9.9%). Participants with T2D were 60.4 ± 8.2 years old, had median follow-up of three visits over 5.3 years, and mean annual change in CNFL was -0.2% (90% CI -14.1% to 14.3%). RCNFL prevalence was 17% overall and was similar...Continue Reading

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Citations

Jun 4, 2020·Journal of Diabetes Investigation·Hoda GadRayaz A Malik
Aug 25, 2020·BMC Medical Informatics and Decision Making·Oleg MetskerValeria V Krzhizhanovskaya
Apr 8, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Sze Hway LimMonty Silverdale
Apr 13, 2021·Journal of Diabetes Science and Technology·Sanjeev SharmaGerry Rayman
May 10, 2021·Clinical Therapeutics·Ioannis N PetropoulosRayaz A Malik
Oct 17, 2021·Oncology and Therapy·Jamie BurgessUazman Alam

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