Rapid correction of low vitamin D status in nursing home residents.

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
R PrzybelskiNeil Binkley

Abstract

This prospective study finds that ergocalciferol 50,000 IU three times weekly for four weeks effectively and safely corrects vitamin D inadequacy in nursing home residents. Low vitamin D status is common among nursing home residents and contributes to bone loss, falls and fractures. The objective of this study was to evaluate the efficacy and safety of short course, high dose, oral vitamin D(2) (ergocalciferol) treatment. This prospective study included 63 nursing home residents. The 25 with low vitamin D status (serum 25(OH)D < or = 25 ng/ml) received oral ergocalciferol 50,000 IU three times weekly for four weeks; the others received no change to their routine care. Serum total 25(OH)D, 25(OH)D(2), 25(OH)D(3), calcium, parathyroid hormone (PTH), bone turnover markers and neuro-cognitive assessments were obtained at baseline and four weeks. Mean total 25(OH)D concentration increased (p < 0.0001) from 17.3 to 63.8 ng/ml in the treated group and remained unchanged in the comparison group. Serum 25(OH)D(3) remained stable in the comparison group, but declined (p < 0.0001) with D(2) treatment from 15.4 to 9.1 ng/ml. Serum PTH trended down in the treatment group (p = 0.06). No treatment-induced improvement in ambulation, cognition ...Continue Reading

References

Aug 1, 1992·Calcified Tissue International·R J HeikinheimoS A Rajala
Nov 4, 1989·Lancet·M F HolickJ Wortsman
Feb 1, 1989·American Journal of Physical Medicine & Rehabilitation·I W Rudman, D Rudman
Apr 1, 1996·Clinical Endocrinology·M S SteinJ D Wark
Mar 31, 1998·Lancet·A MalabananM F Holick
Jun 15, 1999·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J Y ReginsterC Gosset
Jun 15, 1999·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S I ZimmermanJ Magaziner
Nov 24, 1999·Journal of the International Neuropsychological Society : JINS·D A Cahn-WeinerA Pfefferbaum
Feb 7, 2001·The Journal of Clinical Endocrinology and Metabolism·D ZehnderM Hewison
Feb 6, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Heike A BischoffMartin Conzelmann
Apr 29, 2004·JAMA : the Journal of the American Medical Association·Heike A Bischoff-FerrariJohn B Wong
Nov 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Laura A G ArmasRobert P Heaney
Mar 3, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Graziano OnderMarco Pahor
Mar 19, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Bess Dawson-HughesReinhold Vieth
Mar 31, 2005·The Journal of Clinical Endocrinology and Metabolism·Michael F HolickAnne E de Papp
May 12, 2005·JAMA : the Journal of the American Medical Association·Heike A Bischoff-FerrariBess Dawson-Hughes
Feb 17, 2006·The New England Journal of Medicine·Rebecca D JacksonUNKNOWN Women's Health Initiative Investigators
Feb 17, 2006·The New England Journal of Medicine·Jean Wactawski-WendeUNKNOWN Women's Health Initiative Investigators
Mar 22, 2006·The Journal of Nutrition·Robert P Heaney
May 16, 2006·Journal of the American Geriatrics Society·Sabina AgrawalNeil C Binkley
Oct 7, 2006·The American Journal of Clinical Nutrition·Lisa A Houghton, Reinhold Vieth
Dec 2, 2006·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Consuelo H WilkinsJohn C Morris
Dec 6, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Russel BurgeAnna Tosteson
Dec 8, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H A Bischoff-Ferrari
Jan 16, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Susan J WhitingMona S Calvo
Feb 10, 2007·Journal of the American Medical Directors Association·John E Morley
Feb 10, 2007·Journal of the American Medical Directors Association·Zulekha HamidDonald Bodenner
Feb 10, 2007·Journal of the American Medical Directors Association·Paul J DrinkaBrian M Goodman
Feb 17, 2007·Journal of the American Geriatrics Society·Kerry E BroeDouglas P Kiel
Jun 9, 2007·The American Journal of Clinical Nutrition·Joan M LappeRobert P Heaney
Dec 20, 2007·The Journal of Clinical Endocrinology and Metabolism·Michael F HolickAndrew D Tannenbaum
Mar 18, 2008·Bone·Allan G Need, B E Christopher Nordin

❮ Previous
Next ❯

Citations

Dec 23, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C J BaconI R Reid
Feb 17, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M LarrosaJ Gratacós
Jun 20, 2013·Zeitschrift für Gerontologie und Geriatrie·R DiekmannD Volkert
Aug 30, 2008·Current Osteoporosis Reports·Neil Binkley, Diane Krueger
Dec 5, 2012·The Journal of Nutrition, Health & Aging·A PetersonJ Quinn
Mar 13, 2009·Southern Medical Journal·Amy H WarrinerJeffrey R Curtis
May 13, 2009·Southern Medical Journal·Alexandra V YamshchikovVin Tangpricha
Sep 11, 2012·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Cédric AnnweilerOlivier Beauchet
Aug 8, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C AnnweilerO Beauchet
Dec 14, 2011·Neuroepidemiology·Cédric Annweiler, Olivier Beauchet
Jul 5, 2012·Dementia and Geriatric Cognitive Disorders·Thorleif EtgenHans Förstl
Dec 17, 2008·Journal of Geriatric Psychiatry and Neurology·David J LlewellynIain A Lang
Sep 26, 2012·Neurology·Cynthia BalionParminder Raina
Jan 21, 2010·Journal of Nutritional Science and Vitaminology·Akiko KuwabaraToshio Okano
May 3, 2014·Archives of Gerontology and Geriatrics·Olivier BruyèreJean-Yves Reginster
Mar 30, 2013·The Journal of Nutrition, Health & Aging·Y RollandUNKNOWN French Group of Geriatrics and NutritIon
Apr 7, 2010·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Sean CarltonKimberly A Cappuzzo
Jul 14, 2010·Archives of Internal Medicine·David J LlewellynDavid Melzer
Apr 25, 2012·Rheumatic Diseases Clinics of North America·Neil BinkleyDiane Krueger
Feb 22, 2011·Journal of the American Medical Directors Association·Oddom DemontieroGustavo Duque
Mar 5, 2016·Molecular Neurodegeneration·Véréna LandelFrançois Féron
Jun 1, 2010·Endocrinology and Metabolism Clinics of North America·Neil BinkleyDiane Krueger
Feb 24, 2010·Clinics in Geriatric Medicine·Nazem Bassil, John E Morley
Nov 4, 2009·Journal of the American Medical Directors Association·John E Morley
Sep 8, 2009·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Neil BinkleyGary Lensmeyer
Dec 24, 2010·Journal of Gerontological Nursing·Jonathan PlantonBarbara J Edlund
Jul 27, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Etienne CavalierJean-Claude Souberbielle
Apr 13, 2012·Journal of the American Geriatrics Society·Cédric AnnweilerOlivier Beauchet
May 5, 2010·Molecular Nutrition & Food Research·Susan J Whiting, Mona S Calvo
Jul 6, 2014·Journal of Internal Medicine·C AnnweilerO Beauchet
Sep 10, 2015·International Journal of Alzheimer's Disease·Anindita BanerjeeSasanka Chakrabarti
Aug 6, 2015·BMC Musculoskeletal Disorders·Valentina SignoriLorenzo Drago
Jun 21, 2015·Journal of the Neurological Sciences·Rolf JordeHenrik Schirmer
Jul 17, 2012·The Journal of Arthroplasty·Aasis UnnanuntanaJoseph M Lane
Jun 4, 2013·Ageing Research Reviews·J van der SchaftM H Emmelot-Vonk
Mar 24, 2012·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Emily T W DemetriouMichael F Holick
Oct 19, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C MarcelliP Dargent-Molina
Apr 27, 2016·Annals of the New York Academy of Sciences·Cédric Annweiler

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
C J BaconI R Reid
The New England Journal of Medicine
Michael F Holick
JAMA : the Journal of the American Medical Association
Heike A Bischoff-FerrariB Dawson-Hughes
Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
B Dawson-HughesReinhold Vieth
© 2022 Meta ULC. All rights reserved