Rapid, cost-efficient fabrication of microfluidic reactors in thermoplastic polymers by combining photolithography and hot embossing

Lab on a Chip
Jesse GreenerEugenia Kumacheva

Abstract

We report a cost-efficient and easy to implement process for fabricating microfluidic reactors in thermoplastic materials. The method includes (i) the fabrication of an imprint template (master), which consists of a photoresist deposited on a metal plate; (ii) the thermoembossing of the reactor features into polymer sheets; (iii) the activation of the embossed and planar thermoplastic surfaces; and (iv) the low-temperature bonding of these surfaces. The generality of the method is established by fabricating microfluidic reactors with a complex geometry in a range of thermoplastic polymers, including cycloolefin, polycarbonate, and UV-transparent acrylic polymers and by the multiple, high-fidelity use of the master.

References

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Citations

Apr 30, 2013·Analytical and Bioanalytical Chemistry·Alicia D PowersSean P Palecek
Feb 10, 2012·Lab on a Chip·Erwin BerthierDavid Beebe
Apr 11, 2012·Lab on a Chip·Sandrine MiserereLaurent Malaquin
Oct 9, 2013·Lab on a Chip·Andrew J CapelMatthew Thurstans
Feb 1, 2011·Journal of Separation Science·Fletcher J AgostinoSergey N Krylov
May 14, 2011·Advanced Materials·Luc GervaisEmmanuel Delamarche
Jun 26, 2014·Angewandte Chemie·Milad AbolhasaniEugenia Kumacheva
Apr 2, 2015·Lab on a Chip·Zhaoyi WangEugenia Kumacheva
Aug 24, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Jordi ComellesElena Martínez
Oct 5, 2011·Analytical Chemistry·Michelle L KovarikNancy L Allbritton
Dec 10, 2016·Lab on a Chip·Tung-Yi LinPeter B Lillehoj
Jul 7, 2011·International Journal of Molecular Sciences·Hao GuFrieder Mugele
May 5, 2018·Scientific Reports·Carlos Matellan, Armando E Del Río Hernández
Jul 14, 2012·Reports on Progress in Physics·Ralf SeemannStephan Herminghaus
Jul 25, 2019·Lab on a Chip·Abdullah T AlsharhanRyan D Sochol
Jun 15, 2020·Photochemistry and Photobiology·Bhanu PrakashAshok Kumar Ganguli
Sep 26, 2020·Beilstein Journal of Nanotechnology·Owen C ErnstTorsten Boeck
Aug 2, 2017·Sensors·Amine Miled, Jesse Greener
Jan 26, 2011·Analytical Chemistry·Edmond W K YoungDavid J Beebe
Aug 29, 2019·ACS Omega·Nischay Kodihalli ShivaprakashJoey Mead
Oct 13, 2021·Advanced Healthcare Materials·Elisabeth PrinceEugenia Kumacheva

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