Rapid cycling triggered by pindolol augmentation of paroxetine, but not with desipramine

Depression
R P Kraus

Abstract

A treatment-resistant depressed patient developed bipolar rapid cycling in response to pindolol augmentation of paroxetine, after failing to respond in any fashion to pindolol added to desipramine. The rapid cycling initially faded, but recurred after the pindolol dose was increased (in combination with paroxetine) in an attempt to treat a relapse into depression. Her differential development of rapid cycling with pindolol in combination with the SSRI is in keeping with the theory that pindolol augmentation operates via a serotonergic mechanism.

Citations

Apr 23, 2003·Biological Psychiatry·Lori L AltshulerMichael J Gitlin
Jan 22, 2010·CNS Drugs·Richard C SheltonSara A Corya
Jun 1, 1997·Journal of Clinical Psychopharmacology·R P Kraus
Feb 2, 1999·The British Journal of Psychiatry : the Journal of Mental Science·R McAskillD Taylor

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