Rapid decline in fitness of mutation accumulation lines of gonochoristic (outcrossing) Caenorhabditis nematodes.

Evolution; International Journal of Organic Evolution
Charles F BaerAmbuj Upadhyay

Abstract

Evolutionary theory predicts that the strength of natural selection to reduce the mutation rate should be stronger in self-fertilizing than in outcrossing taxa. However, the relative efficacy of selection on mutation rate relative to the many other factors influencing the evolution of any species is poorly understood. To address this question, we allowed mutations to accumulate for ∼100 generations in several sets of "mutation accumulation" (MA) lines in three species of gonochoristic (dieocious) Caenorhabditis (C. remanei, C. brenneri, C. sp. 5) as well as in a dioecious strain of the historically self-fertile hermaprohodite C. elegans. In every case, the rate of mutational decay is substantially greater in the gonochoristic taxa than in C. elegans (∼4× greater on average). Residual heterozygosity in the ancestral controls of these MA lines introduces some complications in interpreting the results, but circumstantial evidence suggests the results are not primarily due to inbreeding depression resulting from residual segregating variation. The results suggest that natural selection operates to optimize the mutation rate in Caenorhabditis and that the strength (or efficiency) of selection differs consistently on the basis of mat...Continue Reading

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Oct 15, 2011·Molecular Biology and Evolution·Sen XuMelania E Cristescu
Jan 17, 2014·Proceedings. Biological Sciences·Jeremy C Gray, Asher D Cutter
Apr 7, 2012·Trends in Genetics : TIG·Cristel G ThomasEric S Haag
Jun 9, 2017·Genetics·Henrique TeotónioCharles F Baer

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