Rapid decline of fasting glucose in HCV diabetic patients treated with direct-acting antiviral agents

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
P PavoneV Vullo

Abstract

Association between hepatitis C virus (HCV) infection and diabetes has been widely postulated. Little is known about the effect of direct-acting antiviral agents (DAAs) on glycaemic control. The aim of our study was to evaluate the glycaemic control modifications in a case series of HCV-positive diabetic patients receiving DAAs. We retrospectively evaluated 149 HCV-positive patients in two different institutions affiliated with Sapienza University: Policlinico Umberto I of Rome and Ospedale Santa Maria Goretti of Latina. We were able to identify 29 patients with type 2 diabetes mellitus (19% of total population) who were receiving different interferon-free regimens. During-treatment fasting glucose (FG) values were available for 21 patients, and analysis revealed a statistically significant reduction (p 0.007); reduction mean value was -52.86 mg/dL. A glycated haemoglobin (A1C) value during treatment (at weeks 4, 8 and/or 12) was available for ten patients, and the analysis revealed a statistically significant reduction (p 0.021) with a reduction mean value of -1.95%. Six patients (23%) needed to reduce hypoglycaemic drugs, eight of ten patients showed reduction of A1C and 14 (67%) of 21 patients showed reduced FG during treatm...Continue Reading

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Citations

May 26, 2016·Infectious Agents and Cancer·Lydia TangShyam Kottilil
Nov 3, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C FabrizioG Angarano
Dec 18, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P PavoneV Vullo
Nov 22, 2017·International Journal of Molecular Sciences·Marisa Di PietroRosa Sessa
Nov 22, 2017·The Journal of Infectious Diseases·Chloe S ChaudhuryColleen Hadigan
Mar 3, 2018·Expert Review of Clinical Pharmacology·Francesca Romana PonzianiEdoardo Giovanni Giannini
Jul 12, 2017·Expert Review of Anti-infective Therapy·María Laura Polo, Natalia Laufer
Jul 20, 2018·European Journal of Gastroenterology & Hepatology·Mostafa ElhelbawyImam Waked
Nov 1, 2018·European Journal of Gastroenterology & Hepatology·Matt DriedgerCurtis L Cooper
Dec 21, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Jia LiUNKNOWN CHeCS Investigators
Apr 13, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Adeel A ButtAbdul-Badi Abou-Samra
Sep 22, 2019·International Journal of Molecular Sciences·Mei-Yueh LeeJin-Ching Lee
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Mar 18, 2021·The New England Journal of Medicine·Patrice Cacoub, David Saadoun
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