PMID: 11328264May 1, 2001Paper

Rapid detection of anti-Helicobacter pylori IgG in urine using immunochromatography

Alimentary Pharmacology & Therapeutics
D Y Graham, S Reddy

Abstract

Non-invasive methods to detect the presence of H. pylori infection continue to be refined. To evaluate a new 20-min immunochromatography method (RAPIRUN H. pylori Antibody) for the presence of anti-H. pylori IgG in urine. We used the (13)C-urea breath test to establish H. pylori status. We evaluated the urine test among 104 subjects including 43 with H. pylori infection confirmed by repeatedly positive urea breath tests and 61 H. pylori-negative subjects with repeatedly negative urea breath tests. Forty-one of the 43 subjects with H. pylori infection had a positive rapid urine test with two false negative tests. There were two false positive tests among the 61 with repeatedly negative urea breath tests. The sensitivity, specificity, positive and negative predictive values for the rapid urine test were 95.3%, 96.7%, 95.3%, and 96.7%, respectively. The kit was easy to use and required no special equipment. The rapid immunochromatography method for determination of anti-H. pylori IgG proved to be reliable with excellent sensitivity and specificity and is likely to be useful for both clinical and epidemiological studies.

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Citations

Feb 27, 2007·Journal of Gastroenterology·Hidekazu SuzukiBarry James Marshall
Mar 6, 2002·Alimentary Pharmacology & Therapeutics·H H-X XiaS K Lam
Aug 29, 2002·Helicobacter·Hazel Mitchell, Francis Mégraud
Apr 13, 2007·Clinical Microbiology Reviews·Francis Mégraud, Philippe Lehours
May 7, 2011·Veterinary Medicine International·R C PatraD Swarup
Feb 26, 2009·Digestive Diseases and Sciences·Lam Tung NguyenMasatsugu Moriyama
Jan 30, 2016·BioMed Research International·Ari Fahrial SyamYoshio Yamaoka
Jun 17, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A ShiotaniT Takahashi
Jan 31, 2013·Pediatrics International : Official Journal of the Japan Pediatric Society·Masumi OkudaYoshihiro Fukuda
Aug 5, 2006·Translational Research : the Journal of Laboratory and Clinical Medicine·Antone R OpekunKyoko Tsuchiya
Jun 8, 2006·Diagnostic Microbiology and Infectious Disease·Chien-Yu LuDeng-Chyang Wu
Jan 13, 2006·Diagnostic Microbiology and Infectious Disease·Takatsugu YamamotoShunya Uchida
Apr 15, 2016·Journal of the Chinese Medical Association : JCMA·Mounia El KhadirBahia Bennani
May 31, 2016·Gastroenterology Research and Practice·Maria Pina DorePaolo Usai-Satta
Mar 16, 2018·The Cochrane Database of Systematic Reviews·Lawrence Mj BestKurinchi Selvan Gurusamy
Mar 15, 2005·International Reviews of Immunology·Raivo Uibo
Sep 13, 2008·Expert Review of Molecular Diagnostics·Takatsugu YamamotoYasushi Kuyama
Mar 31, 2010·Expert Review of Gastroenterology & Hepatology·Seiji ShiotaYoshio Yamaoka
Mar 25, 2017·Gastroenterology Research and Practice·Fumio OmataTsuguya Fukui
Jan 17, 2015·Cancer Prevention Research·Takaya ShimuraMarsha A Moses

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