Rapid detection of major depression in epilepsy: a multicentre study.

Lancet Neurology
Frank G GilliamAndres M Kanner

Abstract

Depression is a common comorbid disorder in epilepsy but is not routinely assessed in neurology clinics. We aimed to create a rapid yet accurate screening instrument for major depression in people with epilepsy. We developed a set of 46 items to identify symptoms of depression that do not overlap with common comorbid cognitive deficits or adverse effects of antiepileptic drugs. This preliminary instrument and several reliable and valid instruments for diagnosis of depression on the basis of criteria from the Diagnostic and Statistical Manual IV, depression symptom severity, health status, and toxic effects of medication were applied to 205 adult outpatients with epilepsy. We used discriminant function analysis to identify the most efficient set of items for classification of major depression, which we termed the neurological disorders depression inventory for epilepsy (NDDI-E). Baseline data for 229 demographically similar patients enrolled in two other clinical studies were used for verification of the original observations. The discriminant function model for the NDDI-E included six items. Internal consistency reliability of the NDDI-E was 0.85 and test-retest reliability was 0.78. An NDDI-E score of more than 15 had a specif...Continue Reading

References

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Citations

Mar 19, 2009·Der Nervenarzt·J Bauer, C Kronisch
Jun 12, 2009·Current Neurology and Neuroscience Reports·Andres M Kanner
Apr 8, 2011·Current Treatment Options in Neurology·Katherine H NoeJoseph I Sirven
Nov 23, 2006·Nature Clinical Practice. Neurology·Andrew J Cole
Jul 11, 2008·The New England Journal of Medicine·Jacqueline A French, Timothy A Pedley
Feb 14, 2009·The Clinical Neuropsychologist·David W LoringMorris J Cohen
Mar 14, 2009·The Neurologist·Irene García-MoralesAndrés M Kanner
Dec 6, 2007·Epilepsia·Andres M Kanner
Jun 6, 2009·Epilepsia·Dale C Hesdorffer, Andres M Kanner
Sep 13, 2012·Epilepsia·Sarah L VelissarisSarah J Wilson
Oct 15, 2009·Epilepsy Currents·Andres M Kanner
Sep 1, 2012·Epilepsy Currents·Lisa M BatemanWilliam H Theodore
May 7, 2014·Epilepsy & Behavior : E&B·Jong-Geun SeoSung-Pa Park
May 2, 2008·Neuro-Chirurgie·F-J Baylé, B de Toffol
Jan 21, 2014·Epilepsy & Behavior : E&B·Janelle Wagner
Jun 14, 2014·Epilepsy & Behavior : E&B·Alan B EttingerTim Bancroft
Dec 3, 2014·Epilepsy & Behavior : E&B·Christian Brandt
Feb 24, 2016·Epilepsy & Behavior : E&B·Aleksandar J RistićDragoslav Sokić
Feb 20, 2016·The British Journal of Clinical Psychology·Meryn LechowiczSuncica Lah
Oct 12, 2014·Epilepsy & Behavior : E&B·John O Elliott, Virginia E Richardson
Oct 12, 2014·Epilepsy & Behavior : E&B·Michael PriviteraSheryl R Haut
Dec 3, 2014·Epilepsy & Behavior : E&B·M MulaA M Kanner
Apr 8, 2015·Epilepsy & Behavior : E&B·Marco MulaTim J von Oertzen
Jan 20, 2015·Epilepsy & Behavior : E&B·Jean-Arthur Micoulaud-FranchiAileen McGonigal
Jan 28, 2015·Epilepsy & Behavior : E&B·Mihael DrinovacTim J von Oertzen

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