PMID: 8960098Nov 29, 1996Paper

Rapid detection of the Fc gamma RIIA-H/R 131 ligand-binding polymorphism using an allele-specific restriction enzyme digestion (ASRED)

Journal of Immunological Methods
X M JiangS E McKenzie

Abstract

A polymorphism of the gene for Fc gamma RIIA, arginine (R) or histidine (H) at position 131, alters the ability of the receptor to bind certain IgG subclasses. Identification of the Fc gamma RIIA-H/R 131 genotype has assumed increasing importance in disorders of host defense, immunohematologic diseases and systemic autoimmune disorders. We report a new method for determination of this genotype in which an allele-specific restriction enzyme site is introduced into an Fc gamma RIIA PCR product from genomic DNA, and polymorphism assignment is determined by restriction enzyme digestion followed by agarose gel electrophoresis. This method is more rapid, more reliable and less expensive than currently available methods.

References

Mar 1, 1995·Arthritis and Rheumatism·R P KimberlyJ C Edberg
Oct 1, 1994·The Journal of Infectious Diseases·R G BrediusT A Out
Oct 1, 1993·Annals of Internal Medicine·C A FijenE J Kuijper
May 1, 1993·Immunology Today·J G van de Winkel, P J Capel
Mar 1, 1996·The Journal of Clinical Investigation·J E SalmonR P Kimberly

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Citations

Sep 1, 2005·Journal of Clinical Immunology·Shoichiro TaniuchiYohnosuke Kobayashi
Apr 27, 2013·Human Immunology·Janardan P PandeyEmily Kistner-Griffin
Sep 21, 2006·Journal of the National Cancer Institute·Susana InogèsUNKNOWN Programa para el Estudio y Tratamiento de Hemopatias Malignas study group
Dec 23, 1999·Current Opinion in Hematology·C B Foster, S J Chanock
May 14, 2004·Journal of Thrombosis and Haemostasis : JTH·V MollakiM E Daly
Feb 18, 2011·International Journal of Immunogenetics·C R OliveiraL A Silveira
May 14, 2008·Cancer Genetics and Cytogenetics·Márcia PaivaRui Medeiros
Sep 17, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wen-Kai Weng, Ronald Levy
Aug 21, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wu ZhangHeinz-Josef Lenz
May 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nai-Kong V CheungRichard Gorlick
Feb 9, 2002·American Journal of Hematology·James G TaylorStephen J Chanock
Feb 15, 2011·Critical Care Medicine·Jordi Solé-ViolánCarlos Rodriguez-Gallego
Aug 31, 2004·Genes and Immunity·A M Stewart-AkersP A Morel
Jan 23, 2004·Genes and Immunity·V MagnussonUNKNOWN SLE Genetics Collaboration Group
Jun 6, 2009·European Journal of Clinical Investigation·M SämpiS Hörkkö
Sep 16, 2004·European Journal of Human Genetics : EJHG·Virginia De RoseAlberto Piazza
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