PMID: 2094424Jan 1, 1990Paper

Rapid determination of benzalkonium chloride in pharmaceutical preparations with flow injection liquid-liquid extraction

Journal of Pharmaceutical and Biomedical Analysis
J J HalvaxA Bult

Abstract

Benzalkonium chloride was assayed by on-line extraction of the benzalkonium ion with picrate to chloroform. The absorbance of picrate was measured. The extractions were performed with a home-made flow injection extraction unit. Calibration curves (1.5-180 x 10(-4)% w/v) were straight lines (r = 0.9993) and the relative standard deviation of a series of injections was less than or equal to 2%. Pharmaceutical benzalkonium preparations, containing xylometazoline, timolol, phenylephrine or carbachol could also be assayed. The method was compared with a modified HPLC assay.

References

Dec 1, 1977·The Journal of Pharmacy and Pharmacology·N E RichardsonD A Norton
Aug 1, 1978·The Journal of Pharmacy and Pharmacology·N E RichardsonD A Norton
Mar 1, 1978·Journal of Pharmaceutical Sciences·R M Richards, L M Mizrahi
Jan 27, 1989·Journal of Chromatography·G Bleau, M Desaulniers
Dec 1, 1984·Journal of Pharmaceutical Sciences·Z R Cybulski
Jan 1, 1986·The Journal of Automatic Chemistry·M D de Castro

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