Rapid determination of plasmonic nanoparticle agglomeration status in blood

Biomaterials
Samir V JenkinsYongbin Zhang

Abstract

Plasmonic nanomaterials as drug delivery or bio-imaging agents are typically introduced to biological systems through intravenous administration. However, the potential for agglomeration of nanoparticles in biological systems could dramatically affect their pharmacokinetic profile and toxic potential. Development of rapid screening methods to evaluate agglomeration is urgently needed to monitor the physical nature of nanoparticles as they are introduced into blood. Here, we establish novel methods using darkfield microscopy with hyperspectral detection (hsDFM), single particle inductively-coupled plasma mass spectrometry (spICP-MS), and confocal Raman microscopy (cRM) to discriminate gold nanoparticles (AuNPs) and their agglomerates in blood. Rich information about nanoparticle agglomeration in situ is provided by hsDFM monitoring of the plasmon resonance of primary nanoparticles and their agglomerates in whole blood; cRM is an effective complement to hsDFM to detect AuNP agglomerates in minimally manipulated samples. The AuNPs and the particle agglomerates were further distinguished in blood for the first time by quantification of particle mass using spICP-MS with excellent sensitivity and specificity. Furthermore, the agglome...Continue Reading

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Dec 9, 2015·ACS Nano·Magdiel I SetyawatiDavid T Leong
Jun 23, 2015·Colloids and Surfaces. B, Biointerfaces·Dominic A UrbanAlke Petri-Fink
Jul 3, 2019·Biosensors·Masauso Moses PhiriBarend Christiaan Vorster
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