Rapid development of hepatocellular siderosis after liver transplantation for neonatal hemochromatosis

Transplantation
H EgawaC O Esquivel

Abstract

A male infant with neonatal iron storage disease, also known as neonatal hemochromatosis (NH), underwent orthotopic liver transplantation (OLT) at the age of 55 days. The native liver contained an incidental hepatocellular carcinoma. Scant iron accumulation was found in a biopsy specimen of the implanted liver on the seventh postoperative day (POD); successive biopsies showed increasing siderosis. On POD 62, the patient died of a cardiac arrhythmia. Autopsy showed siderosis at many sites, including the implanted liver. We discuss the possibility that hemochromatosis recurred in the liver allograft and review possible factors contributing to the siderosis.

References

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Citations

Jun 24, 1999·Journal of Perinatal Medicine·E KassemD Kidron
Oct 21, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Mike A Leonis, William F Balistreri
Oct 21, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Fernanda RodriguesGiorgina Mieli-Vergani
Sep 24, 2005·Pediatric Transplantation·Peter F WhitingtonUdeme D Ekong
Jan 16, 1999·Baillière's Clinical Gastroenterology·J R Poley, M J Nowicki
Jul 19, 2002·Clinics in Liver Disease·Milton J Finegold
Jul 15, 1998·Critical Reviews in Clinical Laboratory Sciences·P C Adams
Mar 14, 2002·Critical Reviews in Clinical Laboratory Sciences·M S Tanner
Dec 16, 1998·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·R Jaffe

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