PMID: 6113617Jan 1, 1981Paper

Rapid development of tolerance to the sedative effects of lorazepam and triazolam in rats

Psychopharmacology
S E File

Abstract

Acute administration of lorazepam (0.25 and 0.5 mg/kg) and triazolam (0.075-0.25 mg/kg) significantly reduced the locomotor activity of rats placed in a holeboard for 10 min. Acute injections of lorazepam (0.25 and 0.5 mg/kg) and triazolam (0.05-0.25 mg/kg) also significantly reduced exploration, measured by the number of head-dips and the time spent head-dipping. After 3 days of pretreatment, tolerance developed to the sedative effects of these drugs: lorazepam (0.25 mg/kg) and triazolam (0.05 and 1 mg/kg) were without significant effect, and lorazepam (0.5 mg/kg) had only the effect of half that dose given acutely. Some of this behavioural tolerance could be attributed to changes in drug metabolism, and the development of tolerance did not require continuous presence of drug in brain and plasma.

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Citations

Jan 1, 1986·Psychopharmacology·C M Bradley, A N Nicholson
Jan 1, 1983·Psychopharmacology·R G ListerD J Greenblatt
Jan 1, 1984·Psychopharmacology·S A HenauerL E Hollister
Jan 1, 1985·Psychopharmacology·D N Stephens, H H Schneider
Jul 16, 1982·European Journal of Pharmacology·H C Rosenberg, T H Chiu
Oct 14, 1983·European Journal of Pharmacology·J P Gent, J R Haigh
Aug 29, 1989·European Journal of Pharmacology·C A SannerudR R Griffiths
Oct 10, 1996·European Journal of Pharmacology·S Higgs, S J Cooper
Jan 1, 1990·Journal of Psychiatric Research·D J Nutt
Nov 12, 1984·Life Sciences·S A HenauerL E Hollister
Jan 1, 1988·Life Sciences·D J Nutt, M J Costello
Jan 1, 1993·Life Sciences·W B Mendelson, D Monti
Mar 1, 1985·Pharmacology, Biochemistry, and Behavior·D Treit
Jan 1, 1986·Pharmacology, Biochemistry, and Behavior·A D LêF Grossi
Feb 1, 1986·Pharmacology, Biochemistry, and Behavior·K C Berridge, D Treit
Feb 1, 1986·Pharmacology, Biochemistry, and Behavior·C R PrinceH Anisman
Mar 1, 1987·Pharmacology, Biochemistry, and Behavior·C A Boast, S C Gerhardt
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Aug 1, 1993·Pharmacology, Biochemistry, and Behavior·K R Short, S F Maier
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Jul 6, 2000·Pharmacology, Biochemistry, and Behavior·E E Elliot, J M White

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