Rapid Diagnostic for Point-of-Care Malaria Screening

ACS Sensors
Samantha E McBirneyAndrea M Armani

Abstract

Despite significant success in therapeutic development, malaria remains a widespread and deadly infectious disease in the developing world. Given the nearly 100% efficacy of current malaria therapeutics, the primary barrier to eradication is lack of early diagnosis of the infected population. However, there are multiple strains of malaria. Although significant efforts and resources have been invested in developing antibody-based diagnostic methods for Plasmodium falciparum, a rapid and easy to use screening method capable of detecting all malaria strains has not been realized. Yet, until the entire malaria-infected population receives treatment, the disease will continue to impact society. Here, we report the development of a portable, magneto-optic technology for early stage malaria diagnosis based on the detection of the malaria pigment, hemozoin. Using β-hematin, a hemozoin mimic, we demonstrate detection limits of <0.0081 μg/mL in 500 μL of whole rabbit blood with no additional reagents required. This level corresponds to <26 parasites/μL, a full order of magnitude below clinical relevance and comparable to or less than existing technologies.

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Citations

Jan 9, 2020·Pathogens and Global Health·S Noushin EmamiRaimondas Mozūraitis
Aug 28, 2020·Nursing Forum·Charles R Davis, Mary Ellen Smith Glasgow
Oct 6, 2020·APL Photonics·Maria SolerAndrea M Armani
Jun 28, 2019·Physical Review Applied·Ilja FescenkoVictor M Acosta
Aug 31, 2019·Biomedical Optics Express·Marco MarsanGabriella Cincotti
Apr 22, 2021·Lab on a Chip·Ran AnUmut A Gurkan

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