Rapid diagnostic methods for aspergillosis

Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology
M Gunasekaran, T Sambandam

Abstract

Conventional laboratory methods are always unsatisfactory for the antemortem diagnosis of systemic mycoses, especially aspergillosis, in immunocompromised patients and those with acquired immune deficiency syndrome (AIDS), regardless of their age. There is increasing proof that aspergillosis is not limited to pulmonary, sinus or nasal regions. These facts, plus the high mortality rate, indicate a tremendous need for reliable and rapid methods of diagnosing this infection. Accordingly, refined techniques such as solid-phase radioimmunoassay (SPIRA), crossed-immunoelectrophoresis (CIE), crossed-radioimmunoelectrophoresis (CRIE), radioallergosorbent test (RAST), radioimmunoprecipitation assay (RIPA), paper radioimmunosorbent test (PRIST), computerized enzyme-linked immunosorbent assay (ELISA), biotin avidin enzyme-linked immunosorbent assay and gas-liquid chromatography (GLC) are being considered or used in clinical laboratories for diagnosing aspergillosis. The advantages and limitations of the RIA, ELISA and GLC methods are briefly discussed.

References

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Citations

Feb 24, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·B Tippin, M F Goodman

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Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

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