Rapid diagnostic test for antenatal syphilis screening in low-income and middle-income countries: a systematic review and meta-analysis

BMJ Open
Carmen Phang Romero CasasSue Harnan

Abstract

To undertake a systematic review and meta-analysis to evaluate the test performance including sensitivity and specificity of rapid immunochromatographic syphilis (ICS) point-of-care (POC) tests at antenatal clinics compared with reference standard tests (non-treponemal (TP) and TP tests) for active syphilis in pregnant women. Five electronic databases were searched (PubMed, EMBASE, CRD, Cochrane Library and LILACS) to March 2016 for diagnostic accuracy studies of ICS test and standard reference tests for syphilis in pregnant women. Methodological quality was assessed using QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies). A bivariate meta-analysis was undertaken to generate pooled estimates of diagnostic parameters. Results were presented using a coupled forest plot of sensitivity and specificity and a scatter plot. The methodological quality of the five included studies with regards to risk of bias and applicability concern judgements was either low or unclear. One study was judged as high risk of bias for patient selection due to exclusion of pregnant women with a previous history of syphilis, and one study was judged at high risk of bias for study flow and timing as not all patients were included in the analysis....Continue Reading

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Citations

Feb 27, 2020·The New England Journal of Medicine·Khalil G GhanemPeter A Rice
Jul 25, 2019·Revista da Associação Médica Brasileira·Maurício HachulWanderley Marques Bernardo
Dec 19, 2020·Current Opinion in Obstetrics & Gynecology·Zi-Qi LiewCourtney Olson-Chen
Mar 8, 2021·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Alison UkuJustin C Konje

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