PMID: 11927425Apr 3, 2002Paper

Rapid direct antibiotic susceptibility testing in endophthalmitis

Ophthalmology
Herminia Miño De KasparA Kampik

Abstract

To compare a new rapid antibiotic susceptibility test (RAST) to the conventional method in patients with endophthalmitis. Prospective nonrandomized comparative trial. Intraocular aspirates from 24 consecutive patients with endophthalmitis were tested. Approximately 0.25 ml of vitreous or anterior chamber aspirate was obtained and tested for antibiotic sensitivity using the Kirby-Bauer agar disk diffusion method. Using this conventional testing method, the aspirates were cultured for bacterial growth before antibiotic susceptibility testing (AST). In contrast, for direct RAST, the aspirates were inoculated directly onto agar plates with antibiotic disks without first culturing for bacterial growth. Of the 24 endophthalmitis aspirates studied, 4 (17%) could not be tested by direct RAST because either more than one bacterial species was present or no bacteria were cultured. The remaining 20 cases provided 467 antibiotic-microorganism combinations. The two methods yielded identical susceptibility results in 409 (88%) of the 467 tests. In 42 tests (9%), a minor discrepancy occurred between the conventional method and RAST, in which one resulted in intermediate susceptibility, whereas the other was either resistant or sensitive. Sign...Continue Reading

References

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Citations

Jun 10, 2004·Retina·Rakesh GuptaUNKNOWN Endophthalmitis Research Group
Dec 13, 2006·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·M J KossH M de Kaspar
Feb 24, 2015·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·L CoorevitsG Claeys
Apr 5, 2005·Retina·Herminia Miño de KasparAnselm Kampik

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