Rapid EEG desynchronization and EMG activation induced by intravenous cocaine in freely moving rats: a peripheral, nondopamine neural triggering.

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Eugene A Kiyatkin, M S Smirnov

Abstract

Many important physiological, behavioral, and psychoemotional effects of intravenous (IV) cocaine (COC) are too fast and transient compared with pharmacokinetic predictions, suggesting a possible involvement of peripheral neural mechanisms in their triggering. In the present study, we examined changes in cortical electroencephalogram (EEG) and neck electromyogram (EMG) induced in freely moving rats by IV COC administration at low, reinforcing doses (0.25-1.0 mg/kg) and compared them with those induced by an auditory stimulus and IV COC methiodide, which cannot cross the blood-brain barrier. We found that COC induces rapid, strong, and prolonged EEG desynchronization, associated with decrease in alpha and increase in beta and gamma activities, and EMG activation and that both begin within 2-6 s following the start of a 10-s injection; immediate components of this effect were dose independent. The rapid COC-induced changes in EEG and EMG resembled those induced by an auditory stimulus; the latter effects had shorter onset latencies and durations and were fully blocked during urethane anesthesia. Although urethane anesthesia completely blocked COC-induced EMG activation and rapid components of EEG response, COC still induced EEG d...Continue Reading

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Citations

Apr 16, 2011·Psychopharmacology·Eugene A Kiyatkin, Magalie Lenoir
Jun 10, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Magalie Lenoir, Eugene A Kiyatkin
Jun 14, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Magalie LenoirEugene A Kiyatkin
May 23, 2015·Mediators of Inflammation·Luciano Rezende VilelaGustavo Batista Menezes
Oct 25, 2011·Neuroscience and Biobehavioral Reviews·Gennady G Knyazev
Sep 29, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Junseok A Kim, Karen D Davis
Jul 25, 2018·ACS Chemical Neuroscience·Ernesto SolisEugene A Kiyatkin

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