Rapid effects of deep brain stimulation reactivation on symptoms and neuroendocrine parameters in obsessive-compulsive disorder

Translational Psychiatry
Pelle P de KoningEric Fliers

Abstract

Improvement of obsessions and compulsions by deep brain stimulation (DBS) for obsessive-compulsive disorder (OCD) is often preceded by a rapid and transient mood elevation (hypomania). In a previous study we showed that improvement of mood by DBS for OCD is associated with a decreased activity of the hypothalamus-pituitary adrenal axis. The aim of our present study was to evaluate the time course of rapid clinical changes following DBS reactivation in more detail and to assess their association with additional neuroendocrine parameters. We included therapy-refractory OCD patients treated with DBS (>1 year) and performed a baseline assessment of symptoms, as well as plasma concentrations of thyroid-stimulating hormone (TSH), prolactin, growth hormone, copeptin and homovanillic acid. This was repeated after a 1-week DBS OFF condition. Next, we assessed the rapid effects of DBS reactivation by measuring psychiatric symptom changes using visual analog scales as well as repeated neuroendocrine measures after 30 min, 2 h and 6 h. OCD, anxiety and depressive symptoms markedly increased during the 1-week OFF condition and decreased again to a similar extent already 2 h after DBS reactivation. We found lower plasma prolactin (41% decrea...Continue Reading

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Citations

Sep 2, 2017·Neurosurgical Focus·Michele RizziCarlo Efisio Marras
May 1, 2020·Brain : a Journal of Neurology·Egill Axfjord FridgeirssonDamiaan Denys
Nov 7, 2019·Frontiers in Psychology·Maarten van WestenDamiaan Denys
May 22, 2020·Brain : a Journal of Neurology·Jens Kuhn, Juan Carlos Baldermann
Sep 3, 2020·Chaos·Alexander N ChurilovElvira R Salakhova
Jan 27, 2021·Neuromodulation : Journal of the International Neuromodulation Society·Moein Minbashi MoeiniEsmail Riahi
Jan 26, 2021·Acta Psychiatrica Scandinavica·Sarah Babette HagemanDamiaan Denys
Nov 1, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Maarten van WestenDamiaan Denys
May 15, 2021·The Journal of Neuropsychiatry and Clinical Neurosciences·Nicholas L BormannAaron D Boes
Apr 28, 2021·Brain : a Journal of Neurology·Clemens NeudorferAndres M Lozano
Dec 11, 2017·Best Practice & Research. Clinical Endocrinology & Metabolism·Ferdinand RoelfsemaEric Fliers

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