Abstract
Contribution to Special Issue on Fast effects of steroids. Estrogens affect learning and memory through rapid and delayed mechanisms. Here we review studies on rapid effects on short-term memory. Estradiol rapidly improves social and object recognition memory, spatial memory, and social learning when administered systemically. The dorsal hippocampus mediates estrogen rapid facilitation of object, social and spatial short-term memory. The medial amygdala mediates rapid facilitation of social recognition. The three estrogen receptors, α (ERα), β (ERβ) and the G-protein coupled estrogen receptor (GPER) appear to play different roles depending on the task and brain region. Both ERα and GPER agonists rapidly facilitate short-term social and object recognition and spatial memory when administered systemically or into the dorsal hippocampus and facilitate social recognition in the medial amygdala. Conversely, only GPER can facilitate social learning after systemic treatment and an ERβ agonist only rapidly improved short-term spatial memory when given systemically or into the hippocampus, but also facilitates social recognition in the medial amygdala. Investigations into the mechanisms behind estrogens' rapid effects on short term memo...Continue Reading
Citations
Aug 1, 2018·Genes, Brain, and Behavior·Martin KavaliersElena Choleris
Oct 9, 2019·Journal of Neuroendocrinology·Mira Z HammoudMohammed R Milad
Apr 30, 2020·Anesthesiology·Kai-Kai ZangYu-Qiu Zhang
Aug 14, 2019·The European Journal of Neuroscience·Nicola Brandt, Gabriele M Rune
Oct 22, 2019·Frontiers in Behavioral Neuroscience·Antonella GasbarriAssunta Pompili
Jan 11, 2020·Frontiers in Neuroscience·Xiaowei DingWeifang Rong
Mar 20, 2019·Molecular Brain·Paul A S SheppardLiisa A M Galea
May 28, 2020·Frontiers in Aging Neuroscience·Monica A WagnerYvette P Conley
Aug 28, 2020·Frontiers in Endocrinology·Ricardo LlorenteDaniela Grassi
Feb 15, 2020·Hormones and Behavior·Matheus Macedo-Lima, Luke Remage-Healey
Apr 24, 2021·Psychoneuroendocrinology·Paul A S SheppardElena Choleris
Dec 18, 2019·Frontiers in Neuroendocrinology·C A FinneyM J Morris
Oct 13, 2021·Scientific Reports·Marie-Pierre de BournonvilleCharlotte A Cornil
Jun 23, 2020·Neuroendocrinology·Marilena MarraudinoDaniela Grassi