Rapid Emergence, Subsidence, and Molecular Detection of Escherichia coli Sequence Type 1193-fimH64 , a New Disseminated Multidrug-Resistant Commensal and Extraintestinal Pathogen

Journal of Clinical Microbiology
James R JohnsonRitu Banerjee

Abstract

Escherichia coli sequence type 1193 (ST1193) is an emerging multidrug-resistant pathogen. We performed longitudinal and cross-sectional surveillance for ST1193 among clinical and fecal E. coli isolates from Minneapolis Veterans Affairs Medical Center (VAMC) patients and their household members, other Minnesota centers, and national VAMCs and compared these ST1193 isolates with archival human and canine ST1193 isolates from Australia (2008). We also developed and extensively validated a novel multiplex PCR assay for ST1193 and its characteristic fimH64 (type 1 fimbrial adhesin) allele. We found that ST1193-H64 (where "H64" refers to a phylogenetic subdivision within ST1193 that is characterized by the fimH64 allele), which was uniformly fluoroquinolone resistant, appeared to emerge in the United States in a geographically staggered fashion beginning around 2011. Its prevalence among clinical and fecal E. coli isolates at the Minneapolis VAMC rose rapidly beginning in 2013, peaked in early 2017, and then plateaued or declined. In comparison with other ST14 complex (STc14) isolates, ST1193-H64 isolates were more extensively multidrug resistant, whereas their virulence genotypes were less extensive but included (uniquely) K1 capsul...Continue Reading

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Citations

Oct 17, 2019·The Journal of Antimicrobial Chemotherapy·André BirgyUNKNOWN Group of the National Observatory of Urinary tract Infection due to ESBL-producing Enterobacteriaceae in children
Mar 12, 2020·Frontiers in Microbiology·Miklos FuziAkos Toth
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Jul 20, 2021·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Brian D JohnstonJames R Johnson
Jun 5, 2021·Applied and Environmental Microbiology·Ana Carolina de Mello SantosTânia Aparecida Tardelli Gomes
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Nov 18, 2021·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Elizabeth A CumminsRebecca J Hall

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