PMID: 11606118Oct 19, 2001Paper

Rapid enantiomeric quantification of an antiviral nucleoside agent (D,L-FMAU, 2'-fluoro-5-methyl-beta,D,L-arabinofurano-syluracil) by mass spectrometry

Journal of Medicinal Chemistry
W A TaoB Lampert

Abstract

A novel mass spectrometric method is applied to rapid, accurate (<1%) quantification of chiral Clevudine (L-FMAU, 2'-fluoro-5-methyl-beta,L-arabinofuranosyluracil), a potent antiviral nucleoside agent against hepatitis B virus. Transition metal bound complex ions containing the chiral drug are generated by electrospray ionization mass spectrometry and subjected to collision-induced dissociation. The ratio of the two competitive dissociation rates is related to the enantiomeric composition of the drug mixture, allowing the determination of enantiomeric contamination in the drug.

References

Jun 14, 1999·Angewandte Chemie·Manfred T ReetzDetlef Stöckigt

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Citations

Sep 29, 2011·Journal of the American Society for Mass Spectrometry·Mohamed MajorLaurence Charles
Oct 7, 2004·Journal of the American Society for Mass Spectrometry·Scott GronertKeiko Okamoto
Feb 14, 2006·Journal of the American Society for Mass Spectrometry·Xin CongCarlito B Lebrilla
Jun 26, 2007·Journal of the American Society for Mass Spectrometry·Sangeeta KumariKotamarthi Bhanuprakash
Sep 28, 2005·Expert Opinion on Investigational Drugs·Chee-Kin Hui, George K K Lau
Apr 12, 2017·Analytica Chimica Acta·Xiangying Yu, Zhong-Ping Yao
Jul 2, 2011·European Journal of Mass Spectrometry·Tallagadda SivaleelaMariappanadar Vairamani
Jul 28, 2005·European Journal of Mass Spectrometry·Lianming Wu, R Graham Cooks
May 3, 2007·Mass Spectrometry Reviews·Frantisek Turecek
Feb 28, 2008·Rapid Communications in Mass Spectrometry : RCM·Min-Kwon LeeYong-Ill Lee
Jun 18, 2005·Journal of Mass Spectrometry : JMS·Li MingJin Qinhan
Jul 22, 2005·Journal of Mass Spectrometry : JMS·Alessandra Di TullioFrancesco De Angelis
Mar 17, 2006·Journal of Mass Spectrometry : JMS·Karel LemrJuraj Sevcík
Apr 30, 2003·Journal of Mass Spectrometry : JMS·Lianming WuR G Cooks
Nov 30, 2021·Mass Spectrometry Reviews·Sara CrottiGianluca Bartolucci

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