PMID: 7535928Mar 28, 1995Paper

Rapid endocytosis of a G protein-coupled receptor: substance P evoked internalization of its receptor in the rat striatum in vivo

Proceedings of the National Academy of Sciences of the United States of America
P W MantyhJ E Maggio

Abstract

Studies on cultured cells have shown that agonists induce several types of G protein-coupled receptors to undergo internalization. We have investigated this phenomenon in rat striatum, using substance P (SP)-induced internalization of the SP receptor (SPR) as our model system. Within 1 min of a unilateral striatal injection of SP in the anesthetized rat, nearly 60% of the SPR-immunoreactive neurons within the injection zone display massive internalization of the SPR--i.e., 20-200 SPR+ endosomes per cell body. Within the dendrites the SPR undergoes a striking translocation from the plasma membrane to endosomes, and these dendrites also undergo a morphological reorganization, changing from a structure of rather uniform diameter to one characterized by large, swollen varicosities connected by thin fibers. In both cell bodies and dendrites the number of SPR+ endosomes returns to baseline within 60 min of SP injection. The number of neurons displaying substantial endosomal SPR internalization is dependent on the concentration of injected SP, and the SP-induced SPR internalization is inhibited by the nonpeptide neurokinin 1 receptor antagonist RP-67,580. These data demonstrate that in the central nervous system in vivo, SP induces a ...Continue Reading

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Citations

Jul 19, 2006·Cell and Tissue Research·Chiara SalioAdalberto Merighi
Jul 6, 2006·Amino Acids·K Ebner, N Singewald
Jun 10, 2006·Cellular and Molecular Neurobiology·Patrícia Aline Boer, José Antonio Rocha Gontijo
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Jun 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Shahir S RizkAnthony A Kossiakoff
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