Rapid endothelialization of small diameter vascular grafts by a bioactive integrin-binding ligand specifically targeting endothelial progenitor cells and endothelial cells.

Acta Biomaterialia
Dake HaoAijun Wang

Abstract

Establishing and maintaining a healthy endothelium on vascular and intravascular devices is crucial for the prevention of thrombosis and stenosis. Generating a biofunctional surface on vascular devices to recruit endothelial progenitor cells (EPCs) and endothelial cells (ECs) has proven efficient in promoting in situ endothelialization. However, molecules conventionally used for EPC/EC capturing generally lack structural stability, capturing specificity, and biological functionalities, which have limited their applications. Discovery of effective, specific, and structurally stable EPC/EC capturing ligands is desperately needed. Using the high-throughput One-Bead One-Compound combinatorial library screening technology, we recently identified a disulfide cyclic octa-peptide LXW7 (cGRGDdvc), which possesses strong binding affinity and functionality to EPCs/ECs, weak binding to platelets, and no binding to inflammatory cells. Because LXW7 is cyclic and 4 out of the 8 amino acids are unnatural D-amino acids, LXW7 is highly proteolytically stable. In this study, we applied LXW7 to modify small diameter vascular grafts using a Click chemistry approach. In vitro studies demonstrated that LXW7-modified grafts significantly improved EPC ...Continue Reading

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Citations

Jan 13, 2021·Biomaterials Science·Jonathan DoroginMarian H Hettiaratchi
Dec 17, 2020·Acta Biomaterialia·Raffaella BucciFrancesca Clerici
Mar 6, 2021·The Journal of Investigative Dermatology·Alan V NguyenAthena M Soulika
Mar 2, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Quanchao ZhangYizao Wan
May 14, 2021·APL Bioengineering·Qiao ZhangGeorge A Truskey
Aug 28, 2021·Tissue Engineering and Regenerative Medicine·Ji-Hua LiMin Yao
Oct 12, 2021·Advanced Healthcare Materials·Xin LiuQi Gu

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