PMID: 7528562Jan 1, 1995Paper

Rapid engraftment by peripheral blood progenitor cells mobilized by recombinant human stem cell factor and recombinant human granulocyte colony-stimulating factor in nonhuman primates.

Blood
R G AndrewsI K McNiece

Abstract

We have previously shown that administration of low-dose recombinant human stem cell factor (rhSCF) plus recombinant human granulocyte colony-stimulating factor (rhG-CSF) to baboons mobilizes greater numbers of progenitor cells in the blood than does administration of rhG-CSF alone. The purpose of the present study was to determine whether marrow repopulating cells are present in the blood of nonhuman primates administered low-dose rhSCF plus rhG-CSF, and if present, whether these cells engraft lethally irradiated recipients as rapidly as blood cells mobilized by treatment with rhG-CSF alone. One group of baboons was administered low-dose rhSCF (25 micrograms/kg/d) plus rhG-CSF (100 micrograms/kg/d) while a second group received rhG-CSF alone (100 micrograms/kg/d). Each animal underwent a single 2-hour leukapheresis occurring the day when the number of progenitor cells per volume of blood was maximal. For baboons administered low-dose rhSCF plus rhG-CSF, the leukapheresis products contained 1.8-fold more mononuclear cells and 14.0-fold more progenitor cells compared to the leukapheresis products from animals treated with rhG-CSF alone. All animals successfully engrafted after transplantation of cryopreserved autologous blood ce...Continue Reading

Citations

Sep 30, 2000·Stem Cells·M Körbling
Jan 1, 1995·Journal of Cancer Research and Clinical Oncology·F Takaku
Dec 1, 1995·Current Opinion in Biotechnology·P Hunt, M Foote
Jan 27, 1998·Hematology/oncology Clinics of North America·O P VeibyH R Snodgrass
Feb 27, 2010·Journal of Cellular and Molecular Medicine·Qiang ShiXing L Wang
Jul 30, 2015·Internal Medicine Journal·U GrabmaierS Brunner
Nov 26, 2011·Pathology, Research and Practice·Nicola DanieleFrancesco Zinno
Nov 24, 2004·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Kazuma IkedaMine Harada
Jan 18, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Alex H Chang, Michel Sadelain
Apr 25, 2006·Molecular Therapy : the Journal of the American Society of Gene Therapy·Brian C BeardHans-Peter Kiem

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