Rapid, enhanced, and persistent protection of patients with renal insufficiency by AS02(V)-adjuvanted hepatitis B vaccine

Kidney International
Murielle SurquinSophie Houard

Abstract

The adjuvanted hepatitis B vaccine, HB-AS04, elicits more rapid and persistent protective antibody concentrations than double doses of conventional recombinant vaccines in patients with renal insufficiency. We compared the immunogenicity, reactogenicity, and safety of the AS02(V)-adjuvanted hepatitis B vaccine HB-AS02 with that of HB-AS04. In this phase III, open, randomized study, 151 hepatitis B vaccine-naïve pre-dialysis, peritoneal dialysis, and hemodialysis patients aged 15 years and older received three doses of HB-AS02 at 0, 1, and 6 months. Another 149 similar patients received four doses of HB-AS04 at 0, 1, 2, and 6 months, and all were followed up for 12 months. HB-AS02 elicited more rapid and persistent seroprotection than HB-AS04, with rates of 77 and 39%, respectively, 1 month after the second vaccine dose, and 94 and 79%, respectively, at 12 months. Superiority of HB-AS02 over HB-AS04 in anti-hepatitis B geometric mean concentrations was found at all time points. HB-AS02 was more reactogenic than HB-AS04, but adverse events were mainly transient, of mild to moderate intensity with no reportable vaccine-related serious events. We conclude that a three-dose primary course of HB-AS02 induced more rapid, enhanced, and...Continue Reading

References

Apr 1, 1988·Journal of Hepatology·W JilgF Deinhardt
Jan 25, 2000·American Journal of Nephrology·F Fabrizi, P Martin
Oct 3, 2002·Postgraduate Medical Journal·K Bel'eedL Sellars
Aug 6, 2003·Expert Review of Vaccines·Jay T EvansJory R Baldridge
Dec 5, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Gerald DaRozaAdeera Levin
Oct 27, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Apr 7, 2005·Nature Medicine·Achal PashineJeffrey B Ulmer
May 12, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Dennis A HesselinkWillem Weimar
Oct 14, 2005·Kidney International·Norella Kong Chiew TongMichel Stoffel
Oct 26, 2005·Journal of Gastroenterology and Hepatology·Ping-Nam WongAndrew Km Wong
Dec 22, 2006·Expert Review of Vaccines·Kalifa A Bojang
Mar 23, 2007·Kidney International·W H LimP T Coates
Apr 6, 2007·Expert Review of Vaccines·Michael Kundi
Oct 13, 2007·Expert Review of Vaccines·Nathalie GarçonMarcelle Van Mechelen
Nov 17, 2007·International Journal of Clinical Practice·A RamezaniA Aghakhani
Apr 5, 2008·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Amitis RamezaniArezoo Aghakhani

❮ Previous
Next ❯

Citations

Feb 27, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kai Ming ChowPhilip Kam-Tao Li
May 15, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Laura Labriola, Michel Jadoul
Jan 29, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Laura LabriolaPatrick Goubau
Jul 25, 2012·Therapeutic Delivery·Thanigaivel Shanmugam, Rinti Banerjee
Apr 22, 2011·Expert Review of Vaccines·Nathalie Garçon, Marcelle Van Mechelen
Aug 26, 2014·Expert Review of Vaccines·Alicja E Grzegorzewska
Oct 3, 2012·ISRN Gastroenterology·Mohammad Hossein Somi, Babak Hajipour
Jan 16, 2010·Kidney International·Katherine A Barraclough, E Geoffrey Playford
Apr 29, 2015·Human Vaccines & Immunotherapeutics·Alicja E Grzegorzewska
May 10, 2018·Seminars in Dialysis·Georges KosmadakisDidier Aguilera
Jul 29, 2010·Alimentary Pharmacology & Therapeutics·F FabriziP Martin
Sep 19, 2014·World Journal of Gastroenterology : WJG·Theodoros EleftheriadisIoannis Stefanidis
Jan 30, 2016·The International Journal of Artificial Organs·Fabrizio FabriziPiergiorgio Messa
Aug 24, 2012·Journal of Clinical Gastroenterology·Wai-Kay SetoChing-Lung Lai
Jul 7, 2017·Immune Network·Ji Ung KimHyunwoo Kim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.