PMID: 8944563Oct 1, 1996Paper

Rapid enhancement of brush border glucose uptake after exposure of rat jejunal mucosa to glucose

Gut
P A SharpS K Srai

Abstract

Increased jejunal glucose transport after ingestion of carbohydrate rich diets may reflect higher concentrations of lumenal glucose. Normal processing of carbohydrate causes wide fluctuations in glucose concentration in the jejunal lumen and this raises the question of whether the high lumenal concentrations seen at peak digestion affect glucose uptake. To study the effects of 30 minute exposure of rat jejunal mucosa to glucose on sodium-glucose transporter (SGLT1) mediated glucose transport across the brush border membrane. Jejunal mucosa was exposed in vitro or in vivo to 25 mM glucose or 25 mM mannitol for 30 minutes. In addition, isolated villus enterocytes were incubated with mannitol or glucose for the same time. Brush border membrane vesicles were isolated from these preparations and phlorizin sensitive 3H-D-glucose accumulation was measured. Lumenal glucose in vivo significantly enhanced SGLT1 mediated glucose uptake by 49.2-57.2%. For jejunal loops in vitro, the increase was 32.0-85.2%. Kinetic analysis disclosed a 50% greater Vmax for glucose uptake in each preparation. The facilitated and passive components of uptake were, however, unaffected by prior exposure to glucose. Incubation of villus enterocytes with 25 mM g...Continue Reading

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Citations

Apr 1, 2011·The Proceedings of the Nutrition Society·S P Shirazi-BeecheyM Al-Rammahi
Nov 22, 2001·The Biochemical Journal·R P Ferraris
Oct 10, 1998·European Journal of Clinical Investigation·E S DebnamG K Grimble
May 23, 1998·The Journal of Physiology·D WalkerB H Hirst
May 15, 2007·The Journal of Physiology·Oliver J MaceGeorge L Kellett
Aug 23, 2011·Progress in Neurobiology·Fadi H Mourad, Nayef E Saadé
Feb 21, 2002·Biochimica Et Biophysica Acta·Mark Williams, Paul Sharp
Jun 18, 2004·American Journal of Physiology. Cell Physiology·Saeed KhoursandiHelmut Kipp
Mar 26, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Anders Lehmann, Pamela J Hornby
Feb 24, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·A TavakkolizadehD B Rhoads
May 30, 2003·American Journal of Physiology. Cell Physiology·Helmut KippRolf K H Kinne
Feb 28, 2004·Experimental Biology and Medicine·Yasuhiro KimuraRandal K Buddington
Aug 24, 2020·Pflügers Archiv : European journal of physiology·Hermann Koepsell

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