Rapid evaluation of risk of white particulate matter in blood components by a statewide survey of transfusion reactions

Transfusion
M IwamotoM J Kuehnert

Abstract

In January 2003, white particulate matter (WPM) was detected in blood components. Because the composition and cause of WPM was not understood at that time, there was uncertainty about whether WPM could endanger patient safety. To investigate possible adverse patient events associated with WPM, transfusion reaction rates were examined. A questionnaire was distributed to Georgia medical centers. Data collected included the number of components transfused and reported adverse reactions by component type from January 2002 through January 2003, and date, reaction type, and blood supplier for events in January 2003. Of 124 transfusion services contacted, 108 (87%) responded. During the survey period, there were 1213 reported transfusion reactions and 528,412 units transfused, or 2.3 reactions per 1000 units transfused; for RBCs, 2.4 (range, 1.8-3.1); plasma, 1.5 (range, 0.6-3.5); and PLTs, 3.4 (2.1-5.4) per 1000 units. Transfusion reaction rates by component for January 2003 did not differ significantly from the rate for January 2002 or for the calendar year. The 86 reported reactions that occurred in January 2003 were attributed to bacterial contamination (n = 2, 2.3%), other febrile nonhemolytic (n = 49, 57.0%), allergic (n = 14, 1...Continue Reading

References

Nov 1, 1974·Transfusion·R T SolisJ A Zeller
Jan 1, 1982·Vox Sanguinis·J E MenitoveR H Aster
Oct 12, 1999·Vox Sanguinis·M BuschG Nemo
Oct 12, 1999·Vox Sanguinis·J DebeirA Cosson
Apr 19, 2002·JAMA : the Journal of the American Medical Association·Patricia M KopkoMark A Popovsky
Mar 6, 2003·Vox Sanguinis·Jean-Claude Faber
Mar 26, 2003·Archives of Pathology & Laboratory Medicine·Ronald E Domen, Gerald A Hoeltge
May 30, 2003·The New England Journal of Medicine·Martha IwamotoUNKNOWN West Nile Virus in Transplant Recipients Investigation Team

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Citations

Sep 8, 2011·Asian Journal of Transfusion Science·Suchet SachdevRatti Ram Sharma
Jul 1, 2004·Transfusion·Toby L Simon
Jul 12, 2017·Biochemia Medica·Janne CadamuroElisabeth Haschke-Becher
May 10, 2007·Archives of Pathology & Laboratory Medicine·Anne F Eder, Linda A Chambers

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