PMID: 2109090Mar 1, 1990Paper

Rapid evolution in a fraction of the Drosophila nuclear genome

Journal of Molecular Evolution
S D WermanR J Britten

Abstract

Previous observations have indicated that Drosophila DNA contains a component that evolves so rapidly that it fails to hybridize between the DNAs of sibling species. To establish the reality of this component and study its properties, the fraction (about 20%) of Drosophila simulans (Dsim) DNA that fails to hybridize to Drosophila melanogaster (Dmel) DNA has been isolated. The majority of the hybridizable part of this isolated fraction (based on control tests on Dsim DNA) fails to hybridize with Dmel DNA under the conditions used for the initial fractionation. Clones of this fraction do hybridize with Dmel DNA at open criterion producing duplexes with greatly reduced thermal stability, indicating that the underlying process is rapid sequence divergence rather than loss of the homologous sequences by relatively large deletions. Cloned fragments from the nonhybridizing fraction from Dsim are more than 15% divergent from the Dmel homologues, whereas the fraction that does hybridize is only 3-5% divergent. In comparison, synonymous substitutions in the coding regions of five genes show a 9% average divergence between Dsim and Dmel. They appear to be intermediate in their degree of divergence between the hybridizing and nonhybridizin...Continue Reading

References

May 1, 1989·Journal of Molecular Evolution·P M Sharp, W H Li
Aug 25, 1989·Nucleic Acids Research·J KwiatowskiF J Ayala
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·L M KunkelS A Latt
Jan 1, 1987·Journal of Molecular Evolution·C G Sibley, J E Ahlquist
May 20, 1988·Journal of Molecular Biology·C H MartinE M Meyerowitz
Jan 1, 1988·Journal of Molecular Evolution·A CacconeJ R Powell
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M M MiyamotoM R Tennant
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·C H Martin, E M Meyerowitz
Dec 1, 1986·Computer Methods and Programs in Biomedicine·R O Davis
Jan 1, 1982·Journal of Molecular Evolution·L J ZwiebelG P Moore
Jan 1, 1981·Journal of Molecular Evolution·J A HuntR J Britten
Dec 1, 1980·Journal of Molecular Evolution·T J HallR J Britten
Aug 1, 1989·Evolution; International Journal of Organic Evolution·Adalgisa Caccone, Jeffrey R Powell
Jul 1, 1982·Evolution; International Journal of Organic Evolution·J W GrulaR J Britten

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Citations

Mar 1, 1990·Journal of Molecular Evolution·R J Britten
Mar 1, 1990·Journal of Molecular Evolution·A Caccone, J R Powell
Feb 8, 2005·Journal of Molecular Evolution·Humberto QuesadaMontserrat Aguadé
Jun 16, 2005·Genetica·C TortiA R Malacrida
Feb 1, 1996·Insect Molecular Biology·A CacconeJ R Powell
Oct 3, 2001·Journal of Medical Entomology·B A GarcíaJ R Powell
Dec 11, 2008·Medical and Veterinary Entomology·E L SeguraB A García
May 1, 1993·Molecular & General Genetics : MGG·Y Y Shevelyov
Apr 1, 1997·Evolution; International Journal of Organic Evolution·Jennifer M GleasonJeffrey R Powell
Aug 1, 1998·Evolution; International Journal of Organic Evolution·Jennifer M GleasonJeffrey R Powell

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