Rapid evolution of the Helicobacter pylori AlpA adhesin in a high gastric cancer risk region from Colombia

PeerJ
Andrés Julián Gutiérrez-EscobarMaría Mercedes Bravo

Abstract

To be able to survive, Helicobacter pylori must adhere to the gastric epithelial cells of its human host. For this purpose, the bacterium employs an array of adhesins, for example, AlpA. The adhesin AlpA has been proposed as a major adhesin because of its critical role in human stomach colonization. Therefore, understanding how AlpA evolved could be important for the development of new diagnostic strategies. However, the genetic variation and microevolutionary patterns of alpA have not been described in Colombia. The study aim was to describe the variation patterns and microevolutionary process of alpA in Colombian clinical isolates of H. pylori. The existing polymorphisms, which are deviations from the neutral model of molecular evolution, and the genetic differentiation of the alpA gene from Colombian clinical isolates of H. pylori were determined. The analysis shows that gene conversion and purifying selection have shaped the evolution of three different variants of alpA in Colombia.

References

Sep 1, 1992·Allergy Proceedings : the Official Journal of Regional and State Allergy Societies·P J Bianchine, T A Russo
Mar 26, 1999·Gastroenterology·L J Van DoornW G Quint
Dec 22, 1999·Molecular Biology and Evolution·X Gu
Nov 10, 2000·Science·M Lynch, J S Conery
Apr 4, 2001·The Journal of Clinical Investigation·M J Blaser, D E Berg
May 30, 2002·American Journal of Epidemiology·Abraham M Y NomuraMartin J Blaser
Jun 14, 2002·FEBS Letters·Yoshio YamaokaDavid Y Graham
Mar 8, 2003·Science·Daniel FalushSebastian Suerbaum
Feb 3, 2004·The Journal of Clinical Investigation·Martin J Blaser, John C Atherton
Mar 23, 2004·Nucleic Acids Research·Robert C Edgar
Sep 7, 2004·Helicobacter·Guillermo I Perez-PerezHermann Brenner
Feb 11, 2005·Molecular Biology and Evolution·Sergei L Kosakovsky Pond, Simon D W Frost
Apr 9, 2005·World Journal of Gastroenterology : WJG·Jing XueDian-Yuan Zhou
Aug 17, 2005·FEMS Microbiology Letters·Ping CaoTimothy L Cover
Apr 20, 2006·Infection and Immunity·Ewa E HennigTimothy L Cover
Jul 5, 2006·Molecular Biology and Evolution·Sergei L Kosakovsky PondSimon D W Frost
Nov 18, 2006·Bioinformatics·Sergei L Kosakovsky PondSimon D W Frost
May 17, 2007·Nature Reviews. Microbiology·Sebastian Suerbaum, Christine Josenhans
Jun 23, 2007·BMC Genomics·S Manjulata DeviNiyaz Ahmed
Sep 6, 2008·Microbiology and Molecular Biology Reviews : MMBR·Colin R ParrishPeter Daszak
Oct 1, 2008·BMC Bioinformatics·Marcin PawlowskiJanusz M Bujnicki
Jan 24, 2009·Science·Yoshan MoodleyMark Achtman
Apr 22, 2009·International Journal of Cancer. Journal International Du Cancer·Paola BertuccioCarlo La Vecchia
Jun 24, 2009·Infection and Immunity·Stefan OdenbreitRainer Haas
Aug 26, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Y Yamaoka
Dec 4, 2009·BMC Microbiology·Mónica OleastroLurdes Monteiro
Apr 2, 2010·Gut Pathogens·Mohammed Mahdy KhalifaRamy Karam Aziz
Jul 22, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Ahmedin JemalElizabeth M Ward
May 28, 2011·Biology Direct·Sandeep J JosephTimothy D Read
Apr 24, 2012·Molecular Microbiology·Sarah TalaricoNina R Salama
Jul 19, 2012·PLoS Genetics·Ben MurrellSergei L Kosakovsky Pond
Nov 2, 2012·Infection and Immunity·Marion S DorerNina R Salama

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Citations

Feb 26, 2021·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Manouchehr Ahmadi Hedayati, Saeed Salavati

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