Rapid eye movement density shows trends across REM periods but is uncorrelated with NREM delta in young and elderly human subjects

Brain Research Bulletin
Nato DarchiaI Feinberg

Abstract

Saccade-like eye movements are the most prominent phasic component of rapid eye movement (REM) sleep. Eye movement density (EMD) appears to be negatively related to sleep depth. Thus, EMD is depressed by sleep deprivation. We sought to determine in 19 young normal (YN) and 19 elderly normal (EN) subjects: (a) whether EMD is correlated with delta EEG in baseline sleep; (b) whether EMD is increased by daytime naps; and (c) whether EMD patterns across sleep cycles differ in the two age groups. Subjects participated in four separate 2-day recording sessions, each consisting of a baseline night, a daytime nap, and post nap night. EMD was measured as 0.3-2 Hz integrated amplitude (IA)/20 s stage REM. EMD was not correlated with rate of non rapid eye movement (NREM) delta production (power/min) in the baseline sleep of either group. Changes in EMD and delta power/min on post nap nights also were uncorrelated. These data indicate that very strong changes in sleep depth (state) are required to overcome the individual stability (traits) of NREM delta and eye movement density. ANOVA for EMD across REM periods 1-4 showed a significant cycle effect and a significant age x cycle interaction. These effects were mainly due to YNs having depres...Continue Reading

References

Jun 1, 1990·Physiology & Behavior·K DujardinP Leconte
Dec 1, 1988·Archives of General Psychiatry·I Feinberg, J D March
Jun 26, 2001·Psychiatry and Clinical Neurosciences·T HoriUNKNOWN Sleep Computing Committee of the Japanese Society of Sleep Research Society
Jul 19, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·X TanI Feinberg
Mar 1, 2002·Journal of Sleep Research·Sat Bir S KhalsaDerk-Jan Dijk

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Citations

Oct 28, 2005·Nature·Jerome M Siegel
May 10, 2007·Journal of Cognitive Neuroscience·Kevin R PetersCarlyle T Smith
Sep 8, 2010·Journal of Sleep Research·Cristina MarzanoLuigi De Gennaro
Nov 24, 2007·Clinics in Geriatric Medicine·Joseph Roland D Espiritu

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