Rapid eye movements sleep as a predictor of functional outcome after stroke: a translational study

Sleep
Marta PaceClaudio L Bassetti

Abstract

Sleep disturbances are common in acute stroke patients and are linked with a negative stroke outcome. However, it is also unclear which and how such changes may be related to stroke outcome. To explore this link, we performed a sleep electroencephalogram (EEG) study in animals and humans after ischemic stroke. (1) Animal study: 12 male rats were assigned to two groups: ischemia (IS) and sham surgery (Sham). In both groups, sleep architecture was investigated 24 h before surgery and for the following 3 days. (2) Human study: 153 patients with ischemic stroke participating in the SAS-CARE prospective, multicenter cohort study had a polysomnography within 9 days after stroke onset. Functional stroke outcome was assessed by the modified Rankin Scale (mRS) at hospital discharge (short-term outcome) and at a 3-month follow-up (long-term outcome). (1) Animal study: rapid eye movement (REM) sleep was significantly reduced in the IS group compared to the Sham group. (2) Human study: patients with poor short-term functional outcome had a reduction of REM sleep and prolonged REM latency during the acute phase of stroke. REM latency was the only sleep EEG variable found to be significantly related to short- and long-term functional impairm...Continue Reading

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Citations

Jun 9, 2020·Neurorehabilitation and Neural Repair·Melanie K FlemingHeidi Johansen-Berg
Dec 19, 2019·Current Sleep Medicine Reports·H Lee LauAlberto R Ramos
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Jun 7, 2019·General Hospital Psychiatry·Megan A MillerNicole Torrence

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