Rapid functional diversification in the structurally conserved ELAV family of neuronal RNA binding proteins.

BMC Genomics
Marie-Laure Samson

Abstract

The Drosophila gene embryonic lethal abnormal visual system (elav) is the prototype of a gene family present in all metazoans. Its members encode structurally conserved neuronal proteins with three RNA Recognition Motifs (RRM) but they paradoxically act at diverse levels of post-transcriptional regulation. In an attempt to understand the history of this family, we searched for orthologs in eleven completely sequenced genomes, including those of humans, D. melanogaster and C. elegans, for which cDNAs are available. We analyzed 23 orthologs/paralogs of elav, and found evidence of gain/loss of gene copy number. For one set of genes, including elav itself, the coding sequences are free of introns and their products most resemble ELAV. The remaining genes show remarkable conservation of their exon organization, and their products most resemble FNE and RBP9, proteins encoded by the two elav paralogs of Drosophila. Remarkably, three of the conserved exon junctions are both close to structural elements, involved respectively in protein-RNA interactions and in the regulation of sub-cellular localization, and in the vicinity of diverse sequence variations. The data indicate that the essential elav gene of Drosophila is newly emerged, res...Continue Reading

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Citations

Jun 25, 2014·Journal of Neurogenetics·Carmen Mohr, Britta Hartmann
Dec 8, 2010·Archives of Insect Biochemistry and Physiology·Sumiharu NagaokaKumiko Kato
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Feb 27, 2013·Molecular and Cellular Neurosciences·Claudia ColombritaAntonia Ratti
Jul 1, 2015·Molecular and Cellular Biology·Emanuela ZaharievaMatthias Soller

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Datasets Mentioned

BETA
AAF43091
Q15717
Q20084
DS231997
DS232533

Software Mentioned

Fasta
ClustalW
genescan
CLC combined workbench ( CLC bio A / S )
tblastn
ELAV

Related Concepts