May 1, 1989

Rapid growth of a meningioma during pregnancy: relationship with estrogen and progesterone receptors--case report

Neurologia Medico-chirurgica
Y SaitohJ Go

Abstract

Meningiomas are often described as hormone-dependent because of their preponderance in females and their tendency to clinically manifest during or after pregnancy. We describe a case of meningioma that grew rapidly during two pregnancies over a 2-year period. The tumor's rapid growth was confirmed by high-resolution computed tomography. Its estimated doubling time was 110 days. The tumor was removed and found to be a benign meningothelial meningioma. The tumor tissue was positive for estrogen receptors (ERs) and progesterone receptors (PRs). In nine cases, including this one, in which ERs and PRs were measured, the positive rate was much higher for PRs than for ERs; only two were positive for ERs. In the case reported here, it is presumed that the growth of the meningioma was influenced by estrogen and/or progesterone binding to receptors, although it is unclear whether one or both hormones was involved.

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Mentioned in this Paper

Tumor Tissue Sample
Spinal Meningioma
Pregnancy Complications, Neoplastic
Progesterone
X-Ray Computed Tomography
Meningothelial Meningioma
Progesterone [EPC]
Progesterone Measurement
Receptors, Progesterone
Meningioma

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