Rapid HIV-1 testing during labor: a multicenter study

JAMA : the Journal of the American Medical Association
M BulterysMother-Infant Rapid Intervention At Delivery (MIRIAD) Study Group

Abstract

Timely testing of women in labor with undocumented human immunodeficiency virus (HIV) status could enable immediate provision of antiretroviral prophylaxis. To determine the feasibility and acceptance of rapid HIV testing among women in labor and to assess rapid HIV assay performance. The Mother-Infant Rapid Intervention At Delivery (MIRIAD) study implemented 24-hour counseling and voluntary rapid HIV testing for women in labor at 16 US hospitals from November 16, 2001, through November 15, 2003. A rapid HIV-1 antibody test for whole blood was used. Acceptance of HIV testing; sensitivity, specificity, and predictive value of the rapid test; time from blood collection to patient notification of results. There were 91,707 visits to the labor and delivery units in the study, 7381 of which were by eligible women without documentation of HIV testing. Of these, 5744 (78%) women were approached for rapid HIV testing and 4849 (84%) consented. HIV-1 test results were positive for 34 women (prevalence = 7/1000). Sensitivity and specificity of the rapid test were 100% and 99.9%, respectively; positive predictive value was 90% compared with 76% for enzyme immunoassay (EIA). Factors independently associated with higher test acceptance inclu...Continue Reading

Citations

Nov 1, 2005·Women's Health·Claire Thorne, Marie-Louise Newell
Nov 4, 2008·Obstetrics and Gynecology·Naomi K TepperDenise J Jamieson
Jul 2, 2008·Obstetrics and Gynecology·Lisa Rahangdale, Deborah Cohan
Sep 11, 2009·Journal of Perinatology : Official Journal of the California Perinatal Association·C S TungJ Levison
Apr 1, 2008·Journal of Women's Health·Lisa RahangdaleDeborah Cohan
Mar 1, 2008·American Journal of Public Health·Laura M BogartSteven M Asch
Oct 6, 2006·Journal of Clinical Microbiology·Sheldon Campbell, Roger Klein
Feb 13, 2007·Archives of Disease in Childhood·Suzy H M StokesKhaled M K Ismail
May 9, 2008·PLoS Medicine·Nitika Pant PaiShakuntala Chhabra
Mar 3, 2009·BMC Pregnancy and Childbirth·Eugene J KongnyuyRobert J I Leke
May 12, 2009·BMC Women's Health·Christopher A EnakpeneObehi O Enabor
Feb 5, 2010·Journal of Clinical Microbiology·Dramane KaniaUNKNOWN WHO/ANRS 1289 Kesho Bora Study Group in Burkina Faso
Jun 22, 2012·The New England Journal of Medicine·Karin Nielsen-SainesUNKNOWN NICHD HPTN 040/PACTG 1043 Protocol Team
Nov 3, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Katerina A ChristopoulosChristopher D Pilcher
Oct 27, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Anna H van't HoogKevin M Decock
Dec 13, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Rolando M VianiStephen A Spector
May 3, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Freddy PerezFrançois Dabis
Jun 9, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jaco HomsyJonathan Mermin
Dec 20, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Lisa RahangdaleDeborah Cohan
Jul 2, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Karen M MegazziniJeffrey S A Stringer
Oct 19, 2010·Indian Journal of Pediatrics·Chokechai Rongkavilit, Basim I Asmar
Oct 31, 2006·The Pediatric Infectious Disease Journal·Amy Sarah GinsburgCatherine M Wilfert
Dec 16, 2005·Cell Research·Niel T ConstantineRichard Y Zhao
Aug 19, 2005·Current Infectious Disease Reports·Matthew F Chersich, Glenda E Gray
Feb 25, 2005·Current Infectious Disease Reports·Scott KellermanJeff Schulden
Jan 24, 2007·Maternal and Child Health Journal·Rebecca L EaryPatricia M Garcia
Oct 31, 2007·Maternal and Child Health Journal·Mayris P WebberMarc Bulterys
Jan 12, 2010·Maternal and Child Health Journal·Kathrine R TanDenise J Jamieson
Jul 6, 2010·Maternal and Child Health Journal·Judy LevisonJessica A Davila
Dec 24, 2005·Current Opinion in Infectious Diseases·James McIntyre
Apr 17, 2007·Journal of Public Health Management and Practice : JPHMP·Jiehui LiUNKNOWN Tuberculosis Epidemiologic Studies Consortium
Mar 9, 2012·American Journal of Public Health·Karolynn SiegelLisa R Metsch
Mar 29, 2013·AIDS and Behavior·Michael S GordonJosiah D Rich
Nov 16, 2007·The Journal of Perinatal & Neonatal Nursing·Renata L DennisDenise J Jamieson
Aug 5, 2008·Clinical Obstetrics and Gynecology·Jill ClarkDenise J Jamieson
Apr 13, 2006·Current HIV/AIDS Reports·Mary A Vogler
Aug 11, 2005·Current HIV/AIDS Reports·Scott KellermanJeff Schulden
Oct 21, 2005·The New England Journal of Medicine·Scott M Hammer
Jul 14, 2006·The New England Journal of Medicine·Laurence HuangDiane V Havlir

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