PMID: 6413786Aug 1, 1983Paper

Rapid identification of correctly located intracerebroventricular cannula in the rat

Journal of Neuroscience Methods
M P HeyesG Coates

Abstract

We describe a radiographic technique to identify a correctly located cannula in the ventricular system of the rat brain during life. A suspension of thorium dioxide was infused into the left lateral ventricle through a cannula placed in the brain under stereotaxic guidance. Correctly located injections were identified by the presence of a distinct thorium shadow on lateral X-ray of the in situ brain. When 6-hydroxydopamine was co-injected with thorium the resultant depletion of striatal dopamine and the changes in a conditioned avoidance responses were correlated with the degree of spreading of thorium through the ventricular system.

References

May 1, 1971·British Journal of Pharmacology·G R Breese, T D Traylor

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Citations

Feb 18, 1985·Life Sciences·M P HeyesG Coates

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