Rapid Identification of Synthetic Cannabinoids in Herbal Incenses with DART-MS and NMR

Journal of Forensic Sciences
Michael A MarinoLing Huang

Abstract

The usage of herbal incenses containing synthetic cannabinoids has caused an increase in medical incidents and triggered legislations to ban these products throughout the world. Law enforcement agencies are experiencing sample backlogs due to the variety of the products and the addition of new and still-legal compounds. In our study, proton nuclear magnetic resonance (NMR) spectroscopy was employed to promptly screen the synthetic cannabinoids after their rapid, direct detection on the herbs and in the powders by direct analysis in real time mass spectrometry (DART-MS). A simple sample preparation protocol was employed on 50 mg of herbal sample matrices for quick NMR detection. Ten synthetic cannabinoids were discovered in fifteen herbal incenses. The combined DART-MS and NMR methods can be used to quickly screen synthetic cannabinoids in powder and herbal samples, serving as a complementary approach to conventional GC-MS or LC-MS methods.

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Citations

Jul 13, 2016·Drug Testing and Analysis·Simon J Dunne, Jenny P Rosengren-Holmberg
Feb 24, 2017·Journal of Forensic Sciences·Siwon KimSuhkmann Kim
Jul 9, 2017·Drug Testing and Analysis·Evgeny Smolianitski-FabianOvadia Lev
Aug 21, 2019·Rapid Communications in Mass Spectrometry : RCM·Liguo SongJohn E Bartmess
Jul 2, 2019·Journal of Forensic Sciences·Alex J KrotulskiBarry K Logan
Jan 2, 2021·Forensic Science International : Synergy·Nicole S Jones, Jeffrey H Comparin
Feb 13, 2021·Analytical and Bioanalytical Chemistry·Vera L AlvesJosé S Câmara
Feb 19, 2021·Forensic Science International : Synergy·Thomas Castaing-CordierJonathan Farjon

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