Rapid induction of localized bone resorption in the auditory bulla of the Mongolian gerbil, Meriones unguiculatus, by increased air pressure

Calcified Tissue International
R A Chole, D E Chan

Abstract

Osteoclastic bone resorption can be induced within the auditory bulla of the Mongolian gerbil by minute increases in air pressure. The objective of this study was to determine the rate at which osteoclasts are induced in areas of resorption and to compare the rate of osteoblast recruitment. Stainless steel tubes were implanted into the middle ears of 31 male gerbils through which a static pressure of 10 mm Hg above atmospheric was applied. The animals were killed at intervals (0, 1, 2, 4, 6, and 8 days) and the ventral wall of the bulla was studied histomorphometrically. The osteoclast area and osteoclast number were measured along the inner surface of the bone of the bulla; the activity of osteoblasts of the outer surface was also estimated. A significant increase in osteoclasts was found over time (P less than 0.0001). There was no significant increase in osteoclasts at 1 day (P = 0.5) but at 2, 4, 6, and 8 days there was a significant increase (P less than 0.03). Osteoblast activity on the outside of the bulla wall paralleled osteoclast activity. In this quantifiable, experimental system, a localized modeling process may be induced within 2 days without the confounding elements of localized trauma or inflammation inherent in...Continue Reading

References

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Citations

Feb 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R A CholeS P Tinling
Apr 1, 1991·Calcified Tissue International·M C Jungkeit, R A Chole
Mar 9, 2004·Bone·A P BergulaJ A Frangos
May 30, 2006·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Steven P Tinling, Richard A Chole
May 20, 1999·The Laryngoscope·P Cayé-ThomasenK Prellner
Sep 28, 2006·The Laryngoscope·Kristianna H MeyPreben Homøe
Nov 1, 1995·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·B E Sherman, R A Chole
Aug 1, 1993·The Annals of Otology, Rhinology, and Laryngology·R A Chole
Dec 1, 1999·The Annals of Otology, Rhinology, and Laryngology·B E Sherman, R A Chole
Sep 1, 1990·The Annals of Otology, Rhinology, and Laryngology·K Adachi, R A Chole
Jul 13, 2000·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·B E Sherman, R A Chole
Jun 9, 1998·Annals of the New York Academy of Sciences·R A Chole
Jan 23, 1999·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·M J Choo, R A Chole

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