Rapid infusion rituximab is well tolerated in patients with primary CNS lymphoma

CNS Oncology
Lisa ModelevskyThomas Kaley

Abstract

To establish the safety and feasibility of rapidly infusing rituximab over 90 min in patients with primary CNS lymphoma (PCNSL). We retrospectively reviewed all patients with PCNSL who received rapid rituximab infusions (RRI) from January 2016 to January 2017. Primary end point was incidence of infusion reactions. 11 patients received a total of 44 RRIs. Rituximab was dosed at 500 or 750 mg/m2. Premedication included acetaminophen and diphenhydramine. No infusion reactions occurred during any RRI. Two infusions were administered with steroids for neurologic symptoms at baseline (4.5%). Rapid administration of rituximab was safe and feasible for patients with PCNSL and at the higher doses received.

References

Jun 7, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas M HabermannSandra J Horning
Oct 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gaurav D ShahLauren E Abrey
Jul 29, 2009·Leukemia & Lymphoma·Douglas E Ney, Lauren E Abrey
Mar 1, 2012·Asia-Pacific Journal of Clinical Oncology·Dora LangNimit Singhal
Jun 5, 2012·Leukemia & Lymphoma·Lakshmi NayakUNKNOWN North American Brain Tumor Consortium
Sep 4, 2012·Journal of Oncology Practice·Sevcan AtayAfey Arpaci
Mar 26, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Dora S P LangAlan Pearson
Apr 10, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James L RubensteinLawrence D Kaplan
Jan 21, 2017·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Mariana N KerbauyJoachim Yahalom
Jun 24, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christian Grommes, Lisa M DeAngelis
Jul 9, 2017·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Alberto FabbriMonica Bocchia

❮ Previous
Next ❯

Citations

Sep 26, 2020·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Kirollos S HannaBrooke Barlow
Sep 30, 2021·Expert Opinion on Drug Delivery·Stephen P KnowlesRenee P Tannenbaum

❮ Previous
Next ❯

Related Concepts

Related Feeds

CNS Lymphoma

In CNS lymphoma, cancerous cells from lymph tissues or other parts of the body form tumors in the brain and/or spinal cord. Here is the latest research on this rare non-Hodgkin lymphoma.