Rapid magnetic solid-phase extraction based on magnetite/silica/poly(methacrylic acid-co-ethylene glycol dimethacrylate) composite microspheres for the determination of sulfonamide in milk samples

Journal of Chromatography. a
Qiang GaoYu-Qi Feng

Abstract

A novel magnetic solid-phase extraction (MSPE) sorbent, magnetite/silica/poly (methacrylic acid-co-ethylene glycol dimethacrylate) (Fe(3)O(4)/SiO(2)/P(MAA-co-EGDMA)), was developed. This MSPE material was prepared by distillation-precipitation polymerization of MAA and EGDMA in the presence of Fe(3)O(4)/SiO(2) microspheres with the surface containing abundant reactive double bonds. The resultant sorbent material was characterized by elemental analysis, electron microscopy, X-ray diffraction and Fourier-transformed infrared spectroscopy. In this work, eleven sulfonamides (SAs) were selected as model analytes to validate the extraction performance of this new MSPE sorbent. Noticeably, the extraction can be carried out quickly, the extraction time for the SAs onto Fe(3)O(4)/SiO(2)/P(MAA-co-EGDMA) sorbent can be clearly shortened to 0.5 min. The desorption solution of SAs was analyzed by LC-MS/MS, and the results showed that the recoveries of these compounds were in the range of 87.6-115.6%, with relative standard deviations ranging between 0.9% and 10.8%; the limit of detection were in the range of 0.5-49.5 ng/L.

Citations

May 15, 2012·Analytical and Bioanalytical Chemistry·Ivo SafarikMirka Safarikova
May 21, 2013·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Xiao-Lin HouXiang-Dang Du
Jan 2, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Chunzhu JiangDaqian Song
Sep 17, 2013·Analytical and Bioanalytical Chemistry·Lijun XieGangfeng Ouyang
May 9, 2014·Journal of Pharmaceutical and Biomedical Analysis·Jincan HeGongke Li
Jan 29, 2016·Journal of Pharmaceutical and Biomedical Analysis·Anna Białk-BielińskaPiotr Stepnowski
Dec 5, 2014·Environmental Toxicology and Pharmacology·Sara LestonFernando Ramos
Jul 19, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jianrong WuHua He
Sep 28, 2016·Journal of Analytical Methods in Chemistry·Alireza FeizbakhshShokooh Ehteshami
Mar 14, 2019·Journal of the Science of Food and Agriculture·YuXia HuangJinxing He
Feb 12, 2020·Journal of Separation Science·Xintong XieGangfeng Ouyang

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