Rapid manifestation of CNS metastatic disease in a cervical carcinoma patient: a case report

Oncology
John V Brown IiiBram H Goldstein

Abstract

Brain metastases originating from primary cervical carcinoma are very rare. Despite surgery and adjuvant therapy, patient prognosis is extremely unfavorable. Prior studies have reported that the median time from the primary disease's diagnosis to development of CNS metastases is approximately 18 months. A 60-year-old woman was initially diagnosed and treated for FIGO clinical stage IB2 cervical carcinoma in March 2007. She underwent a radical hysterectomy, bilateral salpingo-oophorectomy and peri-aortic lymphadenectomy. Two weeks later, the patient presented with dysmetria and homonymous hemianopsia, which was related to a large right occipital CNS metastasis. The patient had surgery to resect the brain tumor and then received Gamma Knife stereotactic radiosurgery and chemotherapy. The neurological deficits were resolved and the patient's disease status has since remained stable, with five months of follow-up. The incidence of brain metastases originating from primary cervical carcinoma is very rare. Furthermore, the occurrence of CNS metastatic disease manifesting itself within a couple weeks following diagnosis of the primary disease is even more unusual. Since the presenting symptoms of CNS metastatic disease are not well ch...Continue Reading

Citations

Nov 25, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·A MarongiuV Esposito
Mar 15, 2013·Practical Neurology·Josef G HeckmannStefan Ernst
Aug 7, 2012·Journal of Neurosciences in Rural Practice·Ravi DadlaniAlangar Sathya Hegde
Dec 15, 2012·Acta neurochirurgica·Sang-Bong ChungJung-Il Lee
Feb 7, 2015·The Journal of Obstetrics and Gynaecology Research·Yumi SatoMitsutoshi Iwashita
May 14, 2016·Journal of Gynecologic Oncology·Haoran LiXi Cheng
Oct 5, 2019·Surgical Neurology International·Ariel TakayanagiOmid S Tehrani
Feb 13, 2021·Cancers·Mayumi Kobayashi KatoTomoyasu Kato

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